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Synthesis, Characterization and Preliminary in vitro Antibacterial Screening Activity of Metal Complexes Derivatives of 2-{[5-(4-Nitrophenyl)-1,3,4-thiadiazol-2-ylimino]methyl}phenol
Corresponding Author(s) : Yip-Foo Win
Asian Journal of Chemistry,
Vol. 25 No. 8 (2013): Vol 25 Issue 8
Abstract
A total of five new metal complexes derivatives of 2-{[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-ylimino]methyl}phenol (HL) with the metal ions [Ni(II), Cu(II), Zn(II), Cd(II) and Sn(II)] have been successfully prepared in alcoholic medium. The complexes obtained are characterized quantitatively and qualitatively by using microelemental analysis, FTIR spectroscopy, UV-visible spectroscopy, mass spectroscopy, 1H and 13C NMR, magnetic susceptibility and conductivity measurements. From the spectral study, all the complexes obtained as monomeric structure and the metals centre moieties are four-coordinated with distorted tetrahedral geometry except Cu(II) complex which existed as a distorted square planar geometry. The preliminary in vitro antibacterial screening activity revealed that complexes 1-5 showed moderate activity against tested bacterial strains and slightly higher compared to the parent ligand.
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- E.A. Elzahany, K.H. Hegab, S.K.H. Khalil and N.S. Youssef, Aust. J. Basic Appl. Sci., 2, 210 (2008).
- K.M. Gaber, H. Mabrouk and S.S. Al-Shihrt, Egypt. J. Chem., 44, 191 (2001).
- F. Hadizadeh and R. Vosoogh, J. Heterocycl. Chem., 45, 1 (2008).
- S.M. Lu and R.Y. Chen, Org. Preparations Proced. Int., 32, 302 (2000).
- A. Jarrahpour, D. Khalili, E.D. Clercq, C. Salmi and J. Michel, Molecules, 12, 1720 (2007).
- N.H. Al-Sha'alan, Molecules, 12, 1080 (2007).
- A.E. Taggi, A.M. Hafez, H. Wack, B. Young, D. Ferraris and T. Lectka, J. Am. Chem. Soc., 124, 6626 (2002).
- J. Salimon, N. Salih, H. Ibraheem and E. Yousif, Asian J. Chem., 22, 5289 (2010).
- E. Yousif, F. Muaiad and H. Adil, J. Al-Nahrain Univ. (Sci.), 14, 44 (2010).
- E. Yousif, H. Adil and Y. Farina, J. Appl. Sci. Res., 6, 879 (2010).
- E. Yousif and E. Rentschler, J. Al-Nahrain Univ. (Sci.), 13, 86 (2010).
- A. Majeed, E. Yousif and Y. Farina, J. Al-Nahrain Univ. (Sci.), 13, 36 (2010).
- H. Ibraheem, H. Adel, A. Ahmed, N. Salih, J. Salimon, A. Graisa, Y. Farina and E. Yousif, J. Al-Nahrain Univ. (Sci.), 13, 43 (2010).
- E. Yousif, Y. Farina, K. Kasar, A. Graisa and K. Ayid, Am. J. Appl. Sci., 6, 582 (2009).
- R. Sliverstein, G. Bassler and T. Morrill, Spectrometric Identification of Organic Compounds, John-Wiley, New York, edn. 7 (2005).
- K. Nakamoto, Infrared of Inorganic and Coordination Compounds, John-Wiley, New York, edn. 6 (1997).
- N.N. Green Wood and A. Earnshow, Chemistry of the elements, Elsevier Science Ltd., edn. 2 (2002).
- B.N. Figgis, Ligand Field Theory and its Applications, John-Wiley, New York, edn. 1 (2000).
- C.K. Jorgensen, Optical Spectra and Chemical Bonding in Inorganic Compounds, Springer (2004).
- J. Salimon, N. Salih, H. Hussien and E. Yousif, Eur. J. Sci. Res., 31, 256 (2009).
- Y.-F. Win, E. Yousif, A. Majeed and S.-T. Ha, Asian J. Chem., 23, 5009 (2011).
- D.C. Harris, Quantitative Chemical Analysis, W.H. Freeman and Company, New York, edn. 8 (2010).
- E. Yousif, H. Adil, A. Majeed A. Graisa and Y. Farina, ARPN J. Eng. Appl. Sci., 4, 39 (2009).
- S. Frankle, S. Reitman and A.C. Sonnenwir, Gradwol's Clinical Laboratory Method and Diagnosis, C.V. Mosby Co., Germany, edn. 7 (1970).
References
E.A. Elzahany, K.H. Hegab, S.K.H. Khalil and N.S. Youssef, Aust. J. Basic Appl. Sci., 2, 210 (2008).
K.M. Gaber, H. Mabrouk and S.S. Al-Shihrt, Egypt. J. Chem., 44, 191 (2001).
F. Hadizadeh and R. Vosoogh, J. Heterocycl. Chem., 45, 1 (2008).
S.M. Lu and R.Y. Chen, Org. Preparations Proced. Int., 32, 302 (2000).
A. Jarrahpour, D. Khalili, E.D. Clercq, C. Salmi and J. Michel, Molecules, 12, 1720 (2007).
N.H. Al-Sha'alan, Molecules, 12, 1080 (2007).
A.E. Taggi, A.M. Hafez, H. Wack, B. Young, D. Ferraris and T. Lectka, J. Am. Chem. Soc., 124, 6626 (2002).
J. Salimon, N. Salih, H. Ibraheem and E. Yousif, Asian J. Chem., 22, 5289 (2010).
E. Yousif, F. Muaiad and H. Adil, J. Al-Nahrain Univ. (Sci.), 14, 44 (2010).
E. Yousif, H. Adil and Y. Farina, J. Appl. Sci. Res., 6, 879 (2010).
E. Yousif and E. Rentschler, J. Al-Nahrain Univ. (Sci.), 13, 86 (2010).
A. Majeed, E. Yousif and Y. Farina, J. Al-Nahrain Univ. (Sci.), 13, 36 (2010).
H. Ibraheem, H. Adel, A. Ahmed, N. Salih, J. Salimon, A. Graisa, Y. Farina and E. Yousif, J. Al-Nahrain Univ. (Sci.), 13, 43 (2010).
E. Yousif, Y. Farina, K. Kasar, A. Graisa and K. Ayid, Am. J. Appl. Sci., 6, 582 (2009).
R. Sliverstein, G. Bassler and T. Morrill, Spectrometric Identification of Organic Compounds, John-Wiley, New York, edn. 7 (2005).
K. Nakamoto, Infrared of Inorganic and Coordination Compounds, John-Wiley, New York, edn. 6 (1997).
N.N. Green Wood and A. Earnshow, Chemistry of the elements, Elsevier Science Ltd., edn. 2 (2002).
B.N. Figgis, Ligand Field Theory and its Applications, John-Wiley, New York, edn. 1 (2000).
C.K. Jorgensen, Optical Spectra and Chemical Bonding in Inorganic Compounds, Springer (2004).
J. Salimon, N. Salih, H. Hussien and E. Yousif, Eur. J. Sci. Res., 31, 256 (2009).
Y.-F. Win, E. Yousif, A. Majeed and S.-T. Ha, Asian J. Chem., 23, 5009 (2011).
D.C. Harris, Quantitative Chemical Analysis, W.H. Freeman and Company, New York, edn. 8 (2010).
E. Yousif, H. Adil, A. Majeed A. Graisa and Y. Farina, ARPN J. Eng. Appl. Sci., 4, 39 (2009).
S. Frankle, S. Reitman and A.C. Sonnenwir, Gradwol's Clinical Laboratory Method and Diagnosis, C.V. Mosby Co., Germany, edn. 7 (1970).