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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Antifungal Properties of Phenyl Fatty Hydroxamic Acids and Their Copper Complexes Synthesized Based on Canola and Palm Kernel Oils

https://doi.org/10.14233/ajchem.2013.13883
Md Jelas Haron
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Hossein Jahangirian
Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Mohd Halim Shah Ismail
Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Roshanak Rafiee-Moghaddam
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Majid Rezayi
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Kamyar Shameli
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Yadollah Gharayebi
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Yadollah Abdollahi
Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia
Mazyar Peyda
Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
Behnam Mahdavi
School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

Corresponding Author(s) : Md Jelas Haron

mdjelas@science.upm.edu.my

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

Phenyl fatty hydroxamic acids (PFHAs) were synthesized by phenyl hydroxylaminolysis of canola or palm kernel oils using lipozyme TL IM as catalyst. Copper complexes of phenyl fatty hydroxamic acids (copper phenyl fatty hydroxamate (Cu-PFHs)) acids were prepared by stirring the phenyl fatty hydroxamic acids which were dissolved in hexane and copper(II) nitrate solution. The antifungal properties of phenyl fatty hydroxamic acids and its copper(II) complex Cu-PFHs based on canola and palm kernel oils were separately investigated against Candida parapsilosis, Candida albicans and Aspergillus fumigatus by the disc diffusion method using Mueller-Hinton agar. The results showed that antifungal activity of Cu-PFHs is higher than phenyl fatty hydroxamic acids do and also the activity of phenyl fatty hydroxamic acids and Cu-PFHs increase while their concentrations increase. The antifungal activity of phenyl fatty hydroxamic acids and Cu-PFHs are significantly higher than nystatin while use against the A. fumigatus, C. parapsilosis and C. albicans and also are significantly higher than ketoconazole while use against the A. fumigatus.

Keywords

Antifungal activity Phenyl fatty hydroxamic acids Copper phenyl fatty hydroxamate Canola oil Palm Kernel Oil
Jelas Haron, M., Jahangirian, H., Halim Shah Ismail, M., Rafiee-Moghaddam, R., Rezayi, M., Shameli, K., … Mahdavi, B. (2013). Antifungal Properties of Phenyl Fatty Hydroxamic Acids and Their Copper Complexes Synthesized Based on Canola and Palm Kernel Oils. Asian Journal of Chemistry, 25(8), 4183–4188. https://doi.org/10.14233/ajchem.2013.13883
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