Copyright (c) 2013 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
HPLC and Spectrophotometric Determination and Formulation of Quetiapine Fumarate in the Pharmaceutical Dosage Forms
Corresponding Author(s) : L. Edjlali
Asian Journal of Chemistry,
Vol. 25 No. 8 (2013): Vol 25 Issue 8
Abstract
The aim of this work was to develop and validate of assay and dissolution tests for quetiapine fumarate in the pharmaceutical dosage by using HPLC and spectrophotometric analyses. The assay method with HPLC analysis was found to be linear in the concentration range of 80 to 200 μg/mL. The validation included linearity, accuracy and precision. In addition, drug stability in medium was demonstrated. Moreover, a simple and precise UV spectrophotometric technique was used for the determination in dissolution analysis. Linear dependency of UV spectrophotometric method lies in the concentration range of 10 to 30 μg/mL. These proposed methods were sensitive, accurate, repeatable and useful for the routine determination of quetiapine in the tablets.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- L.A. Arvanitis and B.G. Miller, Biol. Psychiatry, 42, 233 (1997).
- D.E. Casey, J. Clin. Psychiatry, 57, 40 (1996).
- M. Riedel, N. Müller, M. Strassnig, I. Spellmann, E. Severus and H.-J. Möller, Neuropsychiatr. Dis. Treat., 3, 219 (2007).
- N.S. Gunasekara and C.M. Spencer, CNS Drugs, 9, 325 (1998).
- T.A. Ketter, J.O. Brooks III, J.C. Hoblyn, A.A. Holland, J.Y. Nam, J.L. Culver, W.K. Marsh and J.C. Bonner, J. Psych. Res., 44, 921 (2010).
- O. Gefvert, M. Bergstrom, B. Langstrom, T. Lundberg, L. Lindstrom and R. Yates, Psychopharmacology-Berl., 135, 119 (1998).
- J.S.E. Hellewell, J. McKellar and J. Raniwalla, Poster Presentation, CINP (1998).
References
L.A. Arvanitis and B.G. Miller, Biol. Psychiatry, 42, 233 (1997).
D.E. Casey, J. Clin. Psychiatry, 57, 40 (1996).
M. Riedel, N. Müller, M. Strassnig, I. Spellmann, E. Severus and H.-J. Möller, Neuropsychiatr. Dis. Treat., 3, 219 (2007).
N.S. Gunasekara and C.M. Spencer, CNS Drugs, 9, 325 (1998).
T.A. Ketter, J.O. Brooks III, J.C. Hoblyn, A.A. Holland, J.Y. Nam, J.L. Culver, W.K. Marsh and J.C. Bonner, J. Psych. Res., 44, 921 (2010).
O. Gefvert, M. Bergstrom, B. Langstrom, T. Lundberg, L. Lindstrom and R. Yates, Psychopharmacology-Berl., 135, 119 (1998).
J.S.E. Hellewell, J. McKellar and J. Raniwalla, Poster Presentation, CINP (1998).