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Synthesis and Micellization of Thermo/pH-Responsive Block Copolymer Poly(2-(diethylamino)ethylmethacrylate)-block-poly(N-isopropylacrylamide) Prepared via RAFT Polymerization
Corresponding Author(s) : Chenglin Wu
Asian Journal of Chemistry,
Vol. 25 No. 7 (2013): Vol 25 Issue 7
Abstract
Double hydrophilic block copolymer, poly[2-(diethylamino)ethyl methacrylate]-block-poly(N-isopropylacrylamide), PDEAEMA-b-PNIPAM, was successfully synthesized with good control via reversible addition fragmentation chain transfer radical polymerization (RAFT) with 4-cyanopentanoic acid dithiobenzoate (CPADB) as chain transfer agent in 1,4-dioxane. The diblock copolymer forms core-shell micelles in aqueous solution in dependence of pH and temperature. The behaviour of the double responsive block copolymer in solution was investigated by 1H NMR and UV-visible. Cloud points measurements indicated that the the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) segment was decreased with increasing pH value of the solution, whereas the pKa value of PDEAEMA segment was about pH 7.5.
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- G. Mountrichas and S. Pispas, Macromolecules, 39, 4767 (2006).
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References
G. Mountrichas and S. Pispas, Macromolecules, 39, 4767 (2006).
Z. Ge, D. Xie, D. Chen, X. Jiang, Y. Zhang, H. Liu and S. Liu, Macromolecules, 40, 3538 (2007).
C. Luo, Y. Liu and Z. Li, Macromolecules, 43, 8101 (2010).
M.A.C. Stuart, W.T.S. Huck, J. Genzer, M. Muller, C. Ober, M. Stamm, G.B. Sukhorukov, I. Szleifer, V.V. Tsukruk, M. Urban, F. Winnik, S. Zauscher, I. Luzinov and S. Minko, Nature Mater., 9, 101 (2010).
X. Liu, P. Ni, J. He and M. Zhang, Macromolecules, 43, 4771 (2010).
S. Yu, H. Cölfen, J. Hartmann and M. Antonietti, Adv. Funct. Mater., 12, 541 (2002).
T. Shimoboji, E. Larenas, T. Fowler, A.S. Hoffman and P.S. Stayton, Bioconjug. Chem., 14, 517 (2003).
N. Karanikolopoulos, M. Pitsikalis, N. Hadjichristidis, K. Georgikopoulou, T. Calogeropoulou and J.R. Dunlap, Langmuir, 23, 4214 (2007).
N.M. Moore, C.L. Sheppard and S.E. Sakiyama-Elbert, Acta Biomater., 5, 854 (2009).
S. Liu, J.V.M. Weaver, M. Save and S.P. Armes,Langmuir, 18, 8350 (2002).
J.F. Tan, H.P. Too, T.A. Hatton and K.C. Tam, Langmuir, 22, 3744 (2006).
H.G. Schild, Prog. Polym. Sci., 17, 163 (1992).
R. Nojima, T. Sato, X.P. Qiu and F.M. Winnik, Macromolecules, 41, 292 (2008).
P. Kujawa, F. Tanaka and F.M. Winnik, Macromolecules, 39, 3048 (2006).
C.M. Schilli, M. Zhang, E. Rizzardo, S.H. Zhang, Y.K. Chong, K. Edwards, G. Karlsson and A.H.E. Mulller, Macromolecules, 37, 7861 (2004).
Z. Ge, Y. Cai, J. Yin, Z. Zhu, J. Rao and S. Liu, Langmuir, 23, 1114 (2007).
S.H. Zhang, Y.K. Chong, R.T.A. Mayadunne, G. Moad and E. Rizzardo, Tetrahedron Lett., 40, 2435 (1999).
S.I. Yusa, Y. Shimada, Y. Misukami, T. Yamamoto and Y. Morishima, Macromolecules, 37, 7507 (2004).
J.F. Tan, P. Ravi, H.P. Too, T.A. Hattton and K.C. Tam, Biomacromolecules, 6, 498 (2005).
M. Vamvakaki, D. Palioura,A. Spyros, S.P. Armes and S.H. Anastasiadis, Macromolecules, 39, 5106 (2006)