Issue

Vol. 25 No. 7 (2013): Vol 25 Issue 7

Copyright (c) 2013 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Electrochemical Studies on the Interaction Mechanism of Ternary Cu(II) Complex with DNA

https://doi.org/10.14233/ajchem.2013.13893
Shuangyu Bi
Center for Theoretical Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Haidian District, Beijing100871, P.R. China ; Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Nan Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Jian Zuo
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Pengfei Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Zhen Zhang
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Feng Guo
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China
Yuhua Fan
Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, P.R. China

Corresponding Author(s) : Yuhua Fan

fanyuhua301@163.com

Asian Journal of Chemistry, Vol. 25 No. 7 (2013): Vol 25 Issue 7

Abstract

A new ternary complex of Cu(II) with Schiff base 2-hydroxy-1-naphthaldehyde-glycine (KHL) and 8-hydroxyquinoline (OHQ) was synthesized and characterized by elemental analysis, IR, TG-DTG and molar conductance. The composition of the complex was confirmed to be [Cu(L)(OHQ)]·2H2O. The fundamental electrochemical characteristics of the Cu(II) complex have been studied and the interaction of the copper complex and DNA was also studied by cyclic voltammetry and fluorescence spectra. The results of the cyclic voltammetry showed that the Cu(II) complex had an oxidation peak with the oxidation potential at -0.394 V. After the DNA was added, the peak current declined with the peak potential shifting positively. This suggested that the complex combined with DNA in the form of intercalative binding, which was also proved by the fluorescence analysis. The binding ratio between the Cu(II) ternary complex and DNA was calculated to be 1:1 and the binding constant was 4.6 × 102 L mol-1.

Keywords

Glycine Schiff base Cu(II) complex Cyclic voltammetry DNA
Bi, S., Zhang, N., Zuo, J., Zhang, P., Zhang, Z., Guo, F., & Fan, Y. (2013). Synthesis, Characterization and Electrochemical Studies on the Interaction Mechanism of Ternary Cu(II) Complex with DNA. Asian Journal of Chemistry, 25(7), 4025–4028. https://doi.org/10.14233/ajchem.2013.13893
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Y.H. Fan, S.Y. Bi, Y.Y. Li, C.F. Bi and S.T. Xie, Russ. J. Coord. Chem., 33, 772 (2008).
  2. R.V. Rao, C.P. Rao and E.K. Wegelius, J. Chem. Crystallogr., 33, 139 (2003).
  3. K. Srinivasan, K. Sankaranarayanan, S. Thangavelu and P. Ramasamy, J. Cryst. Growth, 212, 246 (2000).
  4. B.A. Teicher, M.J. Abrams and K.W. Rosbe, Cancer Res., 50, 6971 (1990).
  5. F.M. Antony, R.S. Mahony and M.W. Joyce, Croat. Chem. Acta, 72, 685 (1999).
  6. P. Lumme and H. Elo, Inorg. Chim. Acta, 94, 241 (1984).
  7. W.J. Geary, Coord. Chem. Rev., 7, 81 (1971).
  8. Q.L. Xu, L.J. Sun, H. Li, R.J. Wu and H.G. Wang, Appl. Organomet. Chem., 8, 57 (1994).
  9. M.T. Carter, M. Rodriguez and A.J. Bard, J. Am. Chem. Soc., 111, 8901 (1989).
  10. J. Liu, Q.L. Zou and W.J. Zhang, Metal Based Drugs, 7, 343 (2000)
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0