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Vol. 25 No. 7 (2013): Vol 25 Issue 7

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RP-HPLC Method for Simultaneous Determination of Valsartan and Fenofibrate from PPI Dendrimer

https://doi.org/10.14233/ajchem.2013.13720
P. Sureshkumar
Nova College of Pharmaceutical Education and Research, Jupudi, Ibrahimpatnam-521 456, India
J. Vijaya Ratna
Department of Pharmaceutical Sciences, College of Science and Technology, Andhra University, Visakhapatnam-530 003, India
N. Hematheerthani
Gurram Balnarasiah Institute of Pharmacy, Ghatkear Mandal, RR District-501 301, India

Corresponding Author(s) : P. Sureshkumar

pskumar1974@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 7 (2013): Vol 25 Issue 7

Abstract

The present study aimed at synthesizing PPI dendrimer and loading dual drug followed by developing stability indicating reversed-phase HPLC method and subsequent validation for simultaneous estimation of valsartan and fenofibrate. The proposed RP-HPLC method utilizes a Nucleosil 100, 5 μm, C8, 250 × 4.0 mm column, mobile phase consisting of methanol : 1 % orthophosphoric acid : acetonitrile (45:30:25) and UV detection at 247 nm. The described method was linear over a range of 10-50 μg/mL for valsartan and 3-15 μg/mL for fenofibrate. The mean recoveries were 99.91 and 100.53 % for valsartan and fenofibrate, respectively. Statistical data's were used to check the intermediate precision data obtained under different experimental setups. The calculated value was found to be less than critical value.

Keywords

Valsartan Fenofibrate Dendrimer Simultaneous
Sureshkumar, P., Vijaya Ratna, J., & Hematheerthani, N. (2013). RP-HPLC Method for Simultaneous Determination of Valsartan and Fenofibrate from PPI Dendrimer. Asian Journal of Chemistry, 25(7), 3697–3700. https://doi.org/10.14233/ajchem.2013.13720
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