Synthesis of Novel Benzohydrazides Bearing 4-[3-Methyl-4-(methylsulfonyl)pyridin-2-yl] Moiety as Potential Antibacterial Agents

Swamy Saidugari; V. Lakshmana Rao; K. Vidya; B. Ram; B. Balram

doi:10.14233/ajchem.2016.19448

Issue

Vol. 28 No. 3 (2016): Vol 28 Issue 3

Issue Published : December 5, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Novel Benzohydrazides Bearing 4-[3-Methyl-4-(methylsulfonyl)pyridin-2-yl] Moiety as Potential Antibacterial Agents

https://doi.org/10.14233/ajchem.2016.19448

Swamy Saidugari

Mylan Laboratories Limited, Bollaram, Jinnaram (Mandal), Medak502 325, India; JNTU-H College of Engineering, Nachupally (Kondagattu), Kodimyal Mandal, Jagityal, Karimnagar-505 327, India

V. Lakshmana Rao

Mylan Laboratories Limited, Bollaram, Jinnaram (Mandal), Medak502 325, India

K. Vidya

JNTU-H College of Engineering, Nachupally (Kondagattu), Kodimyal Mandal, Jagityal, Karimnagar-505 327, India

B. Ram

Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India

B. Balram

Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India

Corresponding Author(s) : Swamy Saidugari

swamysaidugari2015@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 3 (2016): Vol 28 Issue 3
Article Published : December 5, 2015

Abstract

This work reports the synthesis and antibacterial activity of novel hydrazone derivatives 8a-k bearing 4-[3-methyl-4-(methylsulfonyl)pyridin-2-yl] moiety. Spectroscopic techniques like ¹H NMR, mass and IR tools was utilized for the characterization of these hydrazone derivatives. The synthesized hydrazone derivatives were tested against a set of bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes by paper disc diffusion method. Compounds 8b, 8d, 8e, 8f, 8h, 8i showed good antibacterial activity against the test organisms.

Keywords

Antibacterial activity Hydrazone 4-Hydroxy benzaldehyde Synthesis

Saidugari, S., Rao, V. L., Vidya, K., Ram, B., & Balram, B. (2015). Synthesis of Novel Benzohydrazides Bearing 4-[3-Methyl-4-(methylsulfonyl)pyridin-2-yl] Moiety as Potential Antibacterial Agents. Asian Journal of Chemistry, 28(3), 639–643. https://doi.org/10.14233/ajchem.2016.19448

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References

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References

G. Uppal, S. Bala, S. Kamboj and M. Saini, Der Pharma. Chem., 3, 250 (2011).

S.N. Pandeya, S.K. Srivastava, P. Rai and A. Singh, J. Sci. Res. Pharm., 1, 92 (2012).

E.S. Coimbra, L.M.R. Antinarelli, A.D. Da Silva, M.L.F. Bispo, C.R. Kaiser and M.V.N. De Souza, Chem. Biol. Drug Des., 81, 658 (2013); doi:10.1111/cbdd.12112.

E.S. Coimbra, A.D. Da Silva, R.M.P. Dias, R.C.N. Corrales, M.L.F. Bispo, C.R. Kaiser and M.V.N. De Souza, Mediter. J. Chem., 1, 106 (2011); doi:10.13171/mjc.1.3.2011.26.09.22.

R.A. Rane and V.N. Telvekar, Bioorg. Med. Chem. Lett., 20, 5681 (2010); doi:10.1016/j.bmcl.2010.08.026.

S. Rollas and G. Kucukguzel, Molecules, 12, 1910 (2007); doi:10.3390/12081910.

H. Bayrak, A. Demirbas, N. Demirbas and S.A. Karaoglu, Eur. J. Med. Chem., 44, 4362 (2009); doi:10.1016/j.ejmech.2009.05.022.

N. Upmanyu, S. Kumar, M. Kharya, K. Shah and P. Misra, Acta Pol. Pharm., 68, 213 (2011).

M. Deutscher and C. Friedman, in eds.: A.G. Mainous and C. Pomeroy, Management of Antimicrobials in Infectious Diseases: Impact of Antibiotics; Springer Humana Press, New York, pp. 1-6 (2010).

B.W. Behm and D.A. Peura, Expert Rev. Gastroenterol. Hepatol., 5, 439 (2011); doi:10.1586/egh.11.37.

S. Lahiri, L.R. Vadali, S. Saidugari, V.N. Bandlamudi, P. Makam, S.R. Manukonda and D. Datta, Compounds for Producing Substituted Sulfoxides, Process for Producing the Same and Use Thereof, US Patent 8,513,427B2 (2013).

D. Kaushik, S.A. Khan, G. Chawla and S.Kumar, Eur. J. Med. Chem., 45, 3943 (2010); doi:10.1016/j.ejmech.2010.05.049.

S. Han, F.-F. Zhang, X. Xie and J.-Z. Chen, Eur. J. Med. Chem., 74, 73 (2014); doi:10.1016/j.ejmech.2013.12.018.

J.-A. Jiang, J.-L. Du, Z.-G. Wang, Z.-N. Zhang, X. Xu, G.-L. Zheng and Y.-F. Ji, Tetrahedron Lett., 55, 1677 (2014); doi:10.1016/j.tetlet.2013.09.050.

S. Narasimhan, S. Madhavan and K.G. Prasad, Synth. Commun., 27, 385 (1997); doi:10.1080/00397919708006037.

Issue

Vol. 28 No. 3 (2016): Vol 28 Issue 3

Synthesis of Novel Benzohydrazides Bearing 4-[3-Methyl-4-(methylsulfonyl)pyridin-2-yl] Moiety as Potential Antibacterial Agents

Corresponding Author(s) : Swamy Saidugari

Abstract

Keywords

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