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Vol. 25 No. 6 (2013): Vol 25 Issue 6

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Preliminary in vitro Cytotoxic Assay on HepG2 and Antibacterial Screening Activity: Synthesis and Characterization of Organotin(IV) Complexes Derivatives of 2-Methyl-3-nitrobenzoic Acid

https://doi.org/10.14233/ajchem.2013.13783
Yip-Foo Win
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia ; School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Siang-Guan Teoh
School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden Penang, Pulau Pinang, Malaysia
Sie-Tiong Ha
Department of Chemical Science, Faculty of Science, University Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, 31900 Kampar, Perak, Malaysia
Tengku-Sifzizul Tengku-Muhammad
Department of Biological Sciences, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Malaysia
Emad Yousif
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq

Corresponding Author(s) : Yip-Foo Win

williamyfw@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6

Abstract

Three organotin(IV) carboxylate complexes derivatives of 2-methyl-3-nitrobenzoic acid (HL) have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their preliminary in vitro cytotoxic assay on human liver hepatocellular carcinoma cells (HepG2) and antibacterial screening activity. Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. With the exceptional case, based on the spectroscopy studies indicated that one methanol molecule also take part in the coordination to tin(IV) atom moiety in complex 3 resulting the tin(IV) atom exhibited five coordination in solid state. From the preliminary in vitro cytotoxic assay on HepG2 and antibacterial screening activity, triphenyltin(IV) (complex 3) showed slightly better activity compared to diorganotin(IV) complexes (1 and 2).

Keywords

In vitro cytotoxic assay Antibacterial activity
Win, Y.-F., Teoh, S.-G., Ha, S.-T., Tengku-Muhammad, T.-S., & Yousif, E. (2013). Preliminary in vitro Cytotoxic Assay on HepG2 and Antibacterial Screening Activity: Synthesis and Characterization of Organotin(IV) Complexes Derivatives of 2-Methyl-3-nitrobenzoic Acid. Asian Journal of Chemistry, 25(6), 3376–3380. https://doi.org/10.14233/ajchem.2013.13783
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