Issue

Vol. 25 No. 6 (2013): Vol 25 Issue 6

Copyright (c) 2013 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Highly Sensitive Spectrofluorimetric Determination of Doxycycline Using Doxycycline-Europiumion-Sodium Dodecyl Sulfonate System

https://doi.org/10.14233/ajchem.2013.13648
Baoxiu Jia
College of Pharmaceutical, Taishan Medical University, Tai'an 271016, P.R. China
Ping Zhang
Branch of Tai'an Central Hospital, Tai'an 271000, P.R. China
Renliang Wang
College of Pharmaceutical, Taishan Medical University, Tai'an 271016, P.R. China
Yuqin Li
College of Pharmaceutical, Taishan Medical University, Tai'an 271016, P.R. China
Caihong Liu
College of Pharmaceutical, Taishan Medical University, Tai'an 271016, P.R. China
Li Li
College of Pharmaceutical, Taishan Medical University, Tai'an 271016, P.R. China

Corresponding Author(s) : Baoxiu Jia

bxjia@tsmc.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6

Abstract

A new sepctrofluorimetric method for the determination of doxycycline was developed based on its enhancement of the fluorescence intensity of europium ion in the presence of sodium dodecyl sulfonate. The mechanism of fluorescence enhancement was studied. Optimum conditions for the determination of doxycycline were also investigated. The linear range was 0.10-3.00 μg/mL. The detection limit was 1.3 ng/mL. There was no interference from the excipients normally used in tablet formulations and the serum compositions. The proposed method was successfully applied to the determination of doxycycline in tablets and serum.

Keywords

Spectrofluorimetry Europium ion Doxycycline Sodium dodecyl sulfonate
Jia, B., Zhang, P., Wang, R., Li, Y., Liu, C., & Li, L. (2013). Highly Sensitive Spectrofluorimetric Determination of Doxycycline Using Doxycycline-Europiumion-Sodium Dodecyl Sulfonate System. Asian Journal of Chemistry, 25(6), 3321–3324. https://doi.org/10.14233/ajchem.2013.13648
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. L.S. Goodman and A.G. Gilman, The Pharmacological Basis of Therapeutics, McGraw-Hill, New York, edn. 9 (1996).
  2. H.T. Lu, Y. Jiang, H.B. Li, F. Chen and M.H. Wong, Chromatographia, 60, 259 (2004).
  3. G.C. Innocenzo and P. Fabio, J. Agric. Food Chem., 57, 8735 (2009).
  4. I. Rade, K. Javor, K. Samo and S. Borut, Anal. Bioanal. Chem., 387, 695 (2007).
  5. D. Satinsky, L.M.L.D. Santos, H. Sklenarova, P. Solich, M.C.B.S.M. Montenegro and A.N. Araujo, Talanta, 68, 214 (2005).
  6. N. Wangfuengkanagul, W. Siangoroh and O. Chailapakul, Talanta, 64, 1183 (2004).
  7. T. Charoenraks, S. Palaharn, K. Grudpan, W. Siangproh, O. Chailapakul, Talanta, 64, 1247 (2004).
  8. Y. Yu, Y. Lai, X.L. Zheng, J.Zh. Wu, Zh.Y. Long and Ch.S. Liang, Spectrochim. Acta A, 68, 1356 (2007).
  9. Ch. Q. Jiang and L. Luo, Anal. Chim. Acta, 511, 11 (2004).
  10. G.Ch. Han, Y. Peng, Y.Q. Hao, Y.N. Liu and F.M. Zhou, Anal. Chim. Acta, 659, 238 (2010).
  11. L. Qhao, X.L. Yan, J.Ch. Guo, D.H. Wang, L. Li, F.Y. Yan and L.G. Chen, Spectrochim. Acta A, 73, 789 (2009).
  12. B. Tang, H. Zhang and Y. Wang, Spectrochim. Acta A, 61, 2239 (2005).
  13. S.M. Sabry, M. Abdel-Hady, M. Elsayed, O.T. Fahmy and H.M. Maher, J. Pharm . Biomed. Anal., 32, 409 (2003).
  14. A. Önal and O. Sagirli, Spectrochim. Acta A, 72, 68 (2009).
  15. H.E. Abdellatef, M.M. El-Henawee, H.M. El-Sayed and M.M. Ayad, Spectrochim. Acta A, 65, 1087 (2006).
  16. H.M.N.H. Irving, H. Freser and T.S. West, IUPAC. Compendium of Analytical Nomenclature, Definitive Rules, Pergamon Press, Oxford (1978).
  17. H.M.N.H. Irving, H. Freiser and T.S. West, IUPAC Compendium of Analyical Nomencature, Definitive Rules, eds., Pergamon Press, Oxford (1981).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 2 Download : 1