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Vol. 25 No. 5 (2013): Vol 25 Issue 5

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Capillary Electrophoresis Separation of the Six Pairs of Chiral Pharmaceuticals Enantiomers

https://doi.org/10.14233/ajchem.2013.13767
H.B. Xue
Teaching and Research Section of Chemistry, Bengbu Medical College, Bengbu, Anhui Province, P.R. China
Y.N. Jiao
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan Province, P.R. China
H. Li
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan Province, P.R. China

Corresponding Author(s) : H.B. Xue

hongbaoxueqhd@126.com

Asian Journal of Chemistry, Vol. 25 No. 5 (2013): Vol 25 Issue 5

Abstract

Under the given voltage, temperature, wavelength, electrolyte concentration and pH value, the capillary electrophoresis was used in this study to separate six pairs of enantiomers (3-quinine alcohol, tamsulosin, etc.) simultaneously, three types of cyclodextrin being the chiral separation selectors. In order to increase the separation capabilities, the electrolyte was modified by polyethylene glycol 4000, the addition of which greatly improved the chiral separation of the enantiomers. The parameters of chiral separation capabilities were also investigated, including resolutions, theoretical plates, capacity factors, apparent mobilities and retention times. This experiment proves this method a success and that the polyethylene glycol 4000 plays an important role in chiral separation when b-cyclodextrin exists.

Keywords

Capillary electrophoresis Polyethylene glycol 4000 (PEG 4000) Cyclodextrin Enantiomeric separation
Xue, H., Jiao, Y., & Li, H. (2012). Capillary Electrophoresis Separation of the Six Pairs of Chiral Pharmaceuticals Enantiomers. Asian Journal of Chemistry, 25(5), 2742–2746. https://doi.org/10.14233/ajchem.2013.13767
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