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Synthesis and Antioxidant and Antibacterial Activities of Metal-Based Schiff Bases of Nicotinoyl, Isonicotinoyl and Benzoyl Hydrazides
Corresponding Author(s) : Z. Shafiq
Asian Journal of Chemistry,
Vol. 25 No. 5 (2013): Vol 25 Issue 5
Abstract
A series of 15 metal based [Cu(II), Co(II) and Ni(II)] complexes have been synthesized with novel N'-[-(5-hydroxy-2-nitrophenyl)-methylidene]pyridine-4-carbohydrazide (L1), N'-[-1-(2,5-dihydroxyphenyl)ethylidene]pyridine-3-carbohydrazide (L2), N'-[-1-(5-chloro-2- hydroxphenyl)ethylidene]pyridine-3-carbohydrazide (L3), N'-[-1-(5-chloro-2-hydroxyphenyl)ethylidene]pyridine-4-carbohydrazide (L4) and N'-[-1-(2,5-dihydroxyphenyl)ethylidene]-3-hydroxybenzohydrazide (L5) Schiff bases and screened for antioxidant and cytotoxic activities. All these complexes exhibited strong antioxidant activity against DPPH radical. Antibacterial activity assay exhibited MIC50 values of these compounds comparable to standard drugs for both Gram-positive and Gram-negative bacteria.
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- G.D. Yadav, S.S. Joshi and P.S. Lathi, Enzyme Microb. Technol., 36, 217 (2005).
- R. Malhotra, M.S. Malik, J.P. Singh and K.S. Dhindsa, J. Inorg. Biochem., 45, 269 (1992).
- H. Zhang, J. Drewe, B. Tseng, S. Kasibhatla and S.X. Cai, Bioorg. Med. Chem., 12, 3649 (2004).
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- S.G. Kucukguzel, A. Mazi, F. Sahin, S. Ozturk and J. Stables, Eur. J. Med. Chem., 38, 1005 (2003).
- S.G. Kucukguzel, E.E. Oruc, S. Rollas, F. Sahin and A. Ozbek, Eur. J. Med. Chem., 37, 197 (2002).
- S.N. Pandeya, H. Manjula and J.P. Stables, Pharmazie, 56, 121 (2001).
- S.G. Kucukguzel, S. Rollas, I. Kucukguzel and M. Kiraz, Eur. J. Med. Chem., 34, 1093 (1999).
- Z. Shafiq, M. Hussain, M. Yaqub, K. Shafiq, M. Ashraf and H.B. Ahmad, Asian J. Chem, 24, 4623 (2012).
- T.A. Koleva-van-Beek, J.P.H. Linssen, A. de Groot, L.N. Evstatieva, Phytochem. Anal., 13, 8 (2002).
- M. Kaspady, V.K. Narayanaswamy, M. Raju and G.K. Rao, Lett. Drug Design Discov., 6, 21 (2009).
- K. Nakamoto, Infrared Spectra of Inorganic and Coordination Compounds, New York, Wiley Interscience, edn. 2 (1970).
- R.K. Agarwal, J. Indian Chem. Soc., 65, 448 (1988).
- L.J. Bellamy, The Infrared Spectra of Complex Molecules, New York: John Wiley (1971).
- W.W. Simmons, The Saddler Handbook of Protons NMR Spectra, Philadelphia, Saddler Research Laboratories Inc. (1978).
References
G.D. Yadav, S.S. Joshi and P.S. Lathi, Enzyme Microb. Technol., 36, 217 (2005).
R. Malhotra, M.S. Malik, J.P. Singh and K.S. Dhindsa, J. Inorg. Biochem., 45, 269 (1992).
H. Zhang, J. Drewe, B. Tseng, S. Kasibhatla and S.X. Cai, Bioorg. Med. Chem., 12, 3649 (2004).
D. Fournand, A. Arnoud and P. Galzy, J. Mol. Catal. B, 4, 77 (1998).
S.G. Kucukguzel, A. Mazi, F. Sahin, S. Ozturk and J. Stables, Eur. J. Med. Chem., 38, 1005 (2003).
S.G. Kucukguzel, E.E. Oruc, S. Rollas, F. Sahin and A. Ozbek, Eur. J. Med. Chem., 37, 197 (2002).
S.N. Pandeya, H. Manjula and J.P. Stables, Pharmazie, 56, 121 (2001).
S.G. Kucukguzel, S. Rollas, I. Kucukguzel and M. Kiraz, Eur. J. Med. Chem., 34, 1093 (1999).
Z. Shafiq, M. Hussain, M. Yaqub, K. Shafiq, M. Ashraf and H.B. Ahmad, Asian J. Chem, 24, 4623 (2012).
T.A. Koleva-van-Beek, J.P.H. Linssen, A. de Groot, L.N. Evstatieva, Phytochem. Anal., 13, 8 (2002).
M. Kaspady, V.K. Narayanaswamy, M. Raju and G.K. Rao, Lett. Drug Design Discov., 6, 21 (2009).
K. Nakamoto, Infrared Spectra of Inorganic and Coordination Compounds, New York, Wiley Interscience, edn. 2 (1970).
R.K. Agarwal, J. Indian Chem. Soc., 65, 448 (1988).
L.J. Bellamy, The Infrared Spectra of Complex Molecules, New York: John Wiley (1971).
W.W. Simmons, The Saddler Handbook of Protons NMR Spectra, Philadelphia, Saddler Research Laboratories Inc. (1978).