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Synthesis, Characterization and Biological Studies of a Mannich Base N-[Phenyl(pyrrolidin-1-yl)methyl]acetamide and Its VO(IV), Mn(II) and Fe(II) Complexes
Corresponding Author(s) : L. Muruganandam
Asian Journal of Chemistry,
Vol. 25 No. 4 (2013): Vol 25 Issue 4
Abstract
N-[Phenyl(pyrrolidin-1-yl)methyl]acetamide was synthesized using Mannich reaction. The complexes of oxovanadium(IV), manganese(II) and iron(II) with this Mannich base were prepared and characterized by elemental analysis and spectral measurements. The spectral data reveal that the ligand acts as bidentate coordination to the metal ion through the CNC nitrogen and carbonyl oxygen atoms. Based on the UV spectral and magnetic moment data, octahedral geometry is assigned for all the complexes. The antimicrobial screening shows that the complexes are more active than the ligand.
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- L. Reister, L. Iaques and Roland, Pharmacology, 3, 243 (1970).
- N. Raman, A. Kulandaisamy, A. Shanmugam and K. Jeyasubramanian, Trans. Met. Chem., 26, 131 (2001).
- M. Alaudeen, P.G. Suhama and AM. Dorothy, Indian J. Chem., 42A, 1617 (2003).
- S. Rawther and M.R. Gopala Krishnan, J. Indian Chem. Soc., 69, 117 (1992).
- J. Dick, R. Bacalogin and A. Maure, Rev. Roum. Chim., 33, 810 (1967).
- L. Muruganandam, K. Balasubramanian and G.V. Prabhu, Acta Ciencia Indica, (in press).
- L. Muruganandam and K. Krishnakumar, E.-J. Chem., 9, 875 (2012).
- M. Tramontini and L. Angiolini, Mannich Bases-Chemistry and Uses; CRC Press Inc.; USA, (1994).
- K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, John Wiley & Sons, Toronto, Part B, edn. 5, p. 60 (1997).
- J.E. Penner-Hahn, Indian J. Chem., 41A, 13 (2002).
- G. Parkin, Chem. Rev., 104, 699 (2004).
- E. Kimura, T. Gotoh, S. Aoki and M. Shiro, Inorg. Chem., 41, 3239 (2002).
- N. Niklas, O. Walte, F. Hampel and R. Alsfasser, J. Chem. Soc., 3367 (2002).
- U. Pal Chaudhuri, L.R. Whiteaker, L. Yang and R.P. Houser, J. Chem. Soc., Dalton Trans., 1902 (2006).
- R. Hamers and C.H. Casterman, J. Med. Biol., 3, 166 (1972).
- G.L. Eichhorn, Metal Ions Biol. Syst., 10, 1 (1980).
References
L. Reister, L. Iaques and Roland, Pharmacology, 3, 243 (1970).
N. Raman, A. Kulandaisamy, A. Shanmugam and K. Jeyasubramanian, Trans. Met. Chem., 26, 131 (2001).
M. Alaudeen, P.G. Suhama and AM. Dorothy, Indian J. Chem., 42A, 1617 (2003).
S. Rawther and M.R. Gopala Krishnan, J. Indian Chem. Soc., 69, 117 (1992).
J. Dick, R. Bacalogin and A. Maure, Rev. Roum. Chim., 33, 810 (1967).
L. Muruganandam, K. Balasubramanian and G.V. Prabhu, Acta Ciencia Indica, (in press).
L. Muruganandam and K. Krishnakumar, E.-J. Chem., 9, 875 (2012).
M. Tramontini and L. Angiolini, Mannich Bases-Chemistry and Uses; CRC Press Inc.; USA, (1994).
K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, John Wiley & Sons, Toronto, Part B, edn. 5, p. 60 (1997).
J.E. Penner-Hahn, Indian J. Chem., 41A, 13 (2002).
G. Parkin, Chem. Rev., 104, 699 (2004).
E. Kimura, T. Gotoh, S. Aoki and M. Shiro, Inorg. Chem., 41, 3239 (2002).
N. Niklas, O. Walte, F. Hampel and R. Alsfasser, J. Chem. Soc., 3367 (2002).
U. Pal Chaudhuri, L.R. Whiteaker, L. Yang and R.P. Houser, J. Chem. Soc., Dalton Trans., 1902 (2006).
R. Hamers and C.H. Casterman, J. Med. Biol., 3, 166 (1972).
G.L. Eichhorn, Metal Ions Biol. Syst., 10, 1 (1980).