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Syntheses and Characterization of Alkyl-pectin Materials
Corresponding Author(s) : X.F. Zheng
Asian Journal of Chemistry,
Vol. 25 No. 4 (2013): Vol 25 Issue 4
Abstract
The present study is related to develop novel colon specific drug delivery systems using chitosan and pectin as a microbially degradable polymeric carrier. Alkyl-pectin with various degrees of substitution were prepared by heterogeneous alkylation of pectin with alkyl bromide. The results showed that the alkyl-pectin with insolubility can be obtained based on the optimal reaction condition. The ratio of pectin to 1-bromoctane mole number was 1:9, reaction time is 8 h with temperature of 80 ºC and the weight ratio of tetrabutyl ammonium bromide to pectin is 0.5 %. The alkyl-pectin structure were characterized by FT-IR Elemental analyses, differential scanning calorimetry analysis and 1H NMR analysis. The findings of the present study conclusively state that alkyl-pectin are promising for colon targeting of drugs.
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- R. Semdé, K. Amighi, M.J. Devleeschouwer and A.J. Moës,Int. J. Pharm.,197, 169 (2000).
- D.N. Venkatesh, A.K. Reddy, M.K. Samanta and B. Suresh, Asian. J.Pharm., 3, 50 (2009).
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- O. Chambin, G. Dupuis, D. Champion, A. Voilley and Y. Pourcelot,Int. J. Pharm., 321, 86 (2006).
- V. Pillay and R. Fassihi, J. Control. Rel., 59, 229 (1999).
- M. Turkoglu and T. Ugurlu, Eur. J. Pharm. Biopharm., 53, 65 (2002).
- M. Sadeghi and J. Biomate, Nanobiotechnol., 2, 36 (2011).
- S. Farris, K.M. Schaich, L.S. Liu, P.H. Cooke, L. Piergiovanni andK.L. Yam, Food Hydrocol., 25, 61( 2011).
- V.R. Sinha and R. Kumria, Int. J. Pharm., 224, 19 (2001).
- O. Munjeri, J.H. Collett and J.T. Fell, J. Control. Rel., 46, 273 (1997).
- G.S. Macleod, J.H. Collett and J.T. Fell, J. Control. Rel., 58, 303 (1999).
- C. Tribet, Biochimie, 80, 461(1998).
- A. Synytsya, J. Copikova, M. Marounek, P. Mlcochová, L. Sihelníková, S. Skoblya, H. Havlátová, P. Matejka, M. Maryška and V. Machovic, Carbohydr. Polym., 56, 169 (2004).
- I.S. Arvanitoyannis, A. Nakayama and S.I. Aiba, Carbohyd. Polym., 37, 371 (1998).
- L. Heux, J. Brugnerotto, J. Desbrières, M.F. Versali and M. Rinaudo, Biomacromolecules, 1, 746 (2000).
- C.L. Tien, M. Lacroix, P. Ispas-Szabo and M.A. Mateescu, J. Control. Rel., 93, 1 (2003).
References
R. Semdé, K. Amighi, M.J. Devleeschouwer and A.J. Moës,Int. J. Pharm.,197, 169 (2000).
D.N. Venkatesh, A.K. Reddy, M.K. Samanta and B. Suresh, Asian. J.Pharm., 3, 50 (2009).
T. Katav, L.S. Liu, T. Traitel, R. Goldbrt, M. Wolfson and J. Kost, J.Control. Rel., 130, 183 (2008).
O. Chambin, G. Dupuis, D. Champion, A. Voilley and Y. Pourcelot,Int. J. Pharm., 321, 86 (2006).
V. Pillay and R. Fassihi, J. Control. Rel., 59, 229 (1999).
M. Turkoglu and T. Ugurlu, Eur. J. Pharm. Biopharm., 53, 65 (2002).
M. Sadeghi and J. Biomate, Nanobiotechnol., 2, 36 (2011).
S. Farris, K.M. Schaich, L.S. Liu, P.H. Cooke, L. Piergiovanni andK.L. Yam, Food Hydrocol., 25, 61( 2011).
V.R. Sinha and R. Kumria, Int. J. Pharm., 224, 19 (2001).
O. Munjeri, J.H. Collett and J.T. Fell, J. Control. Rel., 46, 273 (1997).
G.S. Macleod, J.H. Collett and J.T. Fell, J. Control. Rel., 58, 303 (1999).
C. Tribet, Biochimie, 80, 461(1998).
A. Synytsya, J. Copikova, M. Marounek, P. Mlcochová, L. Sihelníková, S. Skoblya, H. Havlátová, P. Matejka, M. Maryška and V. Machovic, Carbohydr. Polym., 56, 169 (2004).
I.S. Arvanitoyannis, A. Nakayama and S.I. Aiba, Carbohyd. Polym., 37, 371 (1998).
L. Heux, J. Brugnerotto, J. Desbrières, M.F. Versali and M. Rinaudo, Biomacromolecules, 1, 746 (2000).
C.L. Tien, M. Lacroix, P. Ispas-Szabo and M.A. Mateescu, J. Control. Rel., 93, 1 (2003).