Isolation and Identification of Main Compounds of Lagochilus cabulicus

S. Saeidnia; E. Barari; A. Shakeri; A.R. Gohari

doi:10.14233/ajchem.2013.13117

Issue

Vol. 25 No. 3 (2013): Vol 25 Issue 3

Issue Published : October 8, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Isolation and Identification of Main Compounds of Lagochilus cabulicus

https://doi.org/10.14233/ajchem.2013.13117

S. Saeidnia

Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran

E. Barari

Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran

A. Shakeri

Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran

A.R. Gohari

Medicinal Plants Research Center, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran

Corresponding Author(s) : A.R. Gohari

goharii_a@tums.ac.ir

Asian Journal of Chemistry, Vol. 25 No. 3 (2013): Vol 25 Issue 3
Article Published : October 9, 2012

Abstract

The genus, Lagochilus Bge., belongs to Lamiaceae family and consists of 44 species all over the world, 4 species of which are growing exclusively in Iran. Literature show that there is no report around the isolation and spectral elucidation of the main compounds of the Iranian species, Lagochilus cabulicus Benth. The aim of this study is to determine the main compounds of this species for the first time. Column and thin layer chromatographic methods were used for isolation and purification and spectroscopic data (¹H NMR and ¹³C NMR) were employed for identification of the compounds isolated from ethyl acetate and methanol extracts. From the ethyl acetate and methanol extracts of L. cabulicus, four flavonoid, tricetin 3´-methyl ether (1), quercetin (2), quercetin 3-O-a-L-rhamnopyranosyl (1®6) b-D-glucopyranoside (3), quercetin 3-O-b-D-glucopyranoside (4), two steroids, sitosteryl acetate (5), stigmasteryl acetate (6) and one triterpene, lupeol (7), have been identified. The results show that the main compounds of L. cabulicus are biologically and pharmacologically active flavonol glucosides, sterol acetates and pentacyclic triterpene. There has not found any diterpene (lagochilin), as the main compound, in the aerial parts of L. cabulicus.

Keywords

Lagochilus cabulicus Flavonoid Lupeol Sitosteryl acetate Stigmasteryl acetate

Saeidnia, S., Barari, E., Shakeri, A., & Gohari, A. (2012). Isolation and Identification of Main Compounds of Lagochilus cabulicus. Asian Journal of Chemistry, 25(3), 1509–1511. https://doi.org/10.14233/ajchem.2013.13117

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References

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References

K.H. Rechinger, Flora Iranica, Labiatae, Akademische Druck and Verlagsanatalt, Graz (Austria), No 150, pp. 340-341 (1982).

V. Mozaffarian, A Dictionary of Iranian Plant Names, Farhang Moaser Publication, Tehran, p. 307 (1996).

M.P. Nurmatov, U.N. Zainutdinov, F.G. Kamaev and Kh. A. Aslanov, Khim. Prir. Soedin., 6, 788 (1979).

U.N. Zainutdinov, M.P. Pulatova, T.A. Badalbaeva, R.U. Umarova, Z.I. Mavlyankulova, T.P. Pulatova and Kh. A. Aslanov, Khim. Prir. Soedin., 1, 33 (1994).

U.N. Zainutdinov, Z.I. Mavlyankulova and Kh. A. Aslanov, Chem. Nat. Compd., 11, 287 (1976).

Z.I. Mavlyankulova, Y.S. Dimchuk and T.P. Pulatova,Khim. Prir. Soedin., 6, 849 (1989).

U.N. Zainutdinov and R. Islamov, Khim. Farm. Zh., 20, 583 (1986).

D.A. Rakhimov, M. Kh. Malikova, A.A. Vakhabov, I.O. Ruziev and T.R. Abdurakhmanov, Khim. Prir. Soedin., 2, 313 (1995).

M.Kh. Malikova and D.A. Rakhimov, Chem. Nat. Compd., 33, 438 (1997).

D.A. Rakhimov, M.Kh. Malikova,A.A. Vakhabov, T.R. Abdurakhmanov and O.I. Ruziev, Chem. Nat. Compd., 33, 534 (1997).

S. Taban, Sh. Masoudi, F. Chalabian, B. Delnavaz and A. Rustaiyan, J. Med. Plants, 8, 58 (2009).

L. Zhu and Y.J. Tian, Chinese Chem. Lett., 21, 1097 (2010).

P.K. Agrawal, Carbon-13 NMR of Flavonoids, Elsevier Science, New York, p. 342 (1989).

S. Saeidnia, N. Yassa, R. Rezaeipoor, A. Shafiee, A.R. Gohari, M. Kamalinejad and S. Goodarzy, Daru, 17, 37 (2009).

A.R. Gohari, S. Saeidnia, A.R. Shahverdi, N. Yassa, M. Malmir, K. Mollazade and A.R. Naghinejad, Eur. Asia J. Biol. Sci., 3, 64 (2009).

A.R. Gohari, S. Saeidnia, M. Malmir, M. Yazdanpanah and Y. Ajani, J. Med. Plants, 10, 124 (2011).

L.J. Goad and T. Akihisa, Analysis of Sterols, Blackie Academic and Professional, London, p. 427 (1997).

J. Fotie, D.S. Bohle, M.L. Leimanis, E. Georges, G. Rukunga and A.E. Nkengfack, J. Nat. Prod., 69, 62 (2006).

F.D. Nasrullaev and B.T. Makhsudova, Khim. Prir. Soedin., 4, 582 (1991).

H.J. You, H.J. Ahn and G.E. Ji, J. Agric. Food Chem., 58, 10886 (2010).

M.C. Walton, T.K. McGhie, G.W. Reynolds and W.H. Hendriks, J. Agric. Food Chem., 54, 4913 (2006).

A.R. Santos, R. Niero, V.C. Filho, R.A. Yunes, M.G. Pizzolatti, F. Delle Monache and J.B. Calixto, Planta Med., 61, 329 (1995).

O.S. Chizhov, A.V. Kessenikh, I.P. Yakovlev, B.M. Zolotarev, V.A. Petukhov and N.D. Zelinskii, Tetrahedron Lett., 10, 1361 (1969).

Issue

Vol. 25 No. 3 (2013): Vol 25 Issue 3

Isolation and Identification of Main Compounds of Lagochilus cabulicus

Corresponding Author(s) : A.R. Gohari

Abstract

Keywords

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