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Vol. 28 No. 2 (2016): Vol 28 Issue 2

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Optimization and Comparison of Extraction Methods of Lappaconitine from Aconitum Sinomontanum nakai

https://doi.org/10.14233/ajchem.2016.19410
Wenxiu Sun
College of Food Science and Engineering, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohot 010018, Inner Mongolia, P.R. China; Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada
Shi Zhang
College of Food Science and Engineering, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohot 010018, Inner Mongolia, P.R. China
Yujia Zhao
Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada
Marleny D.A. Saldaña
Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada
Meiling Su
College of Food Science and Engineering, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohot 010018, Inner Mongolia, P.R. China
Tungalag Dong
College of Food Science and Engineering, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohot 010018, Inner Mongolia, P.R. China
Ye Jin
College of Food Science and Engineering, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohot 010018, Inner Mongolia, P.R. China

Corresponding Author(s) : Wenxiu Sun

swx122@126.com

Asian Journal of Chemistry, Vol. 28 No. 2 (2016): Vol 28 Issue 2

Abstract

The optimum extraction conditions for the maximum recovery of lappaconitine from Aconitum sinomontanum nakai with ultrasonic, microwave extraction were determined using response surface methodology. Box-Behnken design with three variables and three levels was employed and response surface plots were constructed according to a second order polynomial model. ANOVA showed that the quadratic model was well fitted. The optimum conditions were obtained through the overlapped contour plot. On the basis of which, a microwave-assisted ultrasonic extraction was built. The highest yields of lappaconitine extracted by the three methods were 0.887, 1.208 and 1.227 %, separately. Compared with the traditional extraction method, the extraction yield increase 10.9, 50.1 and 53.3 %; the extraction time save 87.50, 99.44 and 93.88 %. Finally a comparison of the lappaconitine content was conducted, indicating that Aconitum Sinomontanum nakai root cultured in Qinghai Province China has the highest lappaconitine content.

Keywords

Response surface methodology Lappaconitine Extraction Optimization
Sun, W., Zhang, S., Zhao, Y., Saldaña, M. D., Su, M., Dong, T., & Jin, Y. (2015). Optimization and Comparison of Extraction Methods of Lappaconitine from Aconitum Sinomontanum nakai. Asian Journal of Chemistry, 28(2), 435–440. https://doi.org/10.14233/ajchem.2016.19410
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