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Synthesis and Spectroscopic Studies of Metal Complexes of Schiff Base Derived from 2-Phenyl-3-(p-aminophenyl)-4-quinozolone
Corresponding Author(s) : B.K. Rai
Asian Journal of Chemistry,
Vol. 25 No. 2 (2013): Vol 25 Issue 2
Abstract
Ten coordination compounds of Co(II), Ni(II) and Cu(II) with Schiff base ligand 2-phenyl-3-(p-aminophenyl)-4-quinazolone hydrazone (PAQH) were synthesized and characterized by molar mass elemental analyses, magnetic susceptibility, infrared spectra, electronic spectra and molar conductance measurements. All the synthesized compounds were screened for antimicrobial activities against two bacteria, Escherichia coli and Staphylococcus aureus. Metal complexes exhibit several fold increase in their antimicrobial activity in comparison to that of the constituting ligand fragments. The complexes of Co(II) and Ni(II) were proposed to be octahedral in geometry whereas the geometry of Cu(II) complexes were proposed distorted octahedral.
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- V. Algarsamy, R. Giridhar, M.R. Yadav, R. Revati, K. Ruckmani and E. De. Chercq, Indian J. Pharm. Sci., 69, 304 (2007).
- A.G.A. El-Helby, Acta Pharm., 53, 127 (2003).
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- S.T. Pai and M.W. Platt, Lett. Appl. Microb., 20, 14 (1994).
- P.A.J. Janseen, J. Coordiovase Pharmacol., 7, 52 (1985).
- D.P. Gupta, S. Ahmad, A. Kumar and K. Shankar, Indian J. Chem., 27B, 1060 (1988).
- B.R. Vogt and L.M. Simpkins, Ger. Pat. Offen, 2,916,992 (1979); Chem. Abstr., 92, 111052 (1980).
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- T. Singh, S. Sharma, V. K. Shrivastava and A. Kumar, Indian J. Chem., 45B, 2558 (2006).
- S.R. Pattan, V.V.K. Reddy, F.V. Manvi, B.G. Desai and A.R. Bhat, Indian J. Chem., 45B, 1778 (2006).
- B.K. Rai and K. Sharma, Asian J. Chem., 20, 137 (2008); B.K. Rai, R. Rai, P. Sahi and S. Rana, Asian J. Chem., 20, 143, 149 (2008).
- B.K. Rai, Z. Hussain, U.P. Singh, S.N. Prasad, A. Prasad and P.M. Mishra, Ultra J. Chem., 4, 53 (2008); B.K. Rai and S.N. Prasad, Ultra J. Chem., 4, 71 (2008); B.K. Rai and A. Kumar, Ultra J. Chem.; 4, 179 (2008); B.K. Rai, J. Indian Coun. Chem., 25, 137 (2008); B.K. Rai, A. Baluni, A. Prasad, R. Thakur and P. Prakash, Asian J. Chem., 21, 3708, 3713 (2009).
- B.K. Rai and Vinayak, Ultra J. Chem., 5, 67 (2009); B.K. Rai,A. Kumar and Ravishankar, Ultra J. Chem., 5, 73 (2009); B.K. Rai, S. Kumari, R.K. Singh, A. Prasad, M.P. Sinha and P.M. Mishra, Ultra J. Chem., 5, 83 (2009); A. Prasad and B.K. Rai, Orient J. Chem., 25, 175 (2000); B.K. Rai, Ravishankar and S. Pandey, Asian J Chem., 21, 5409, 5994 (2009); B.K. Rai, A. Prasad, Vinayak, A. Kumar and S. Jha 'Sunit', Asian J. Phys., 18, 63 (2009); B.K. Rai, V. Singh, Vinayak, S.P. Singh and S. Jha ‘Sunit’, Asian J. Phys., 18, 67 (2009); B.K. Rai, J. Indian Coun. Chem., 26, 121 (2009); B.K. Rai, Asian J. Chem., 22, 2761 (2010); B.K. Rai and C. Kumar, Asian J. Chem., 22, 5613 (2010); B.K. Rai and S. Singh, Asian J. Chem., 22, 5619 (2010); B.K. Rai and K.K. Sharma, Asian J. Chem., 22, 5625 (2010).
- B.K. Rai and R. Kumari, Asian J. Chem., 23, 4625 (2011); B.K. Rai, P. Sinha, S.N. Vidyarathi and V. Singh, Asian J. Chem., 23, 4629 (2011); B.K. Rai, V. Singh, S.N. Vidyarathi and P. Sinha, Asian J. Chem., 23, 4638 (2011); B.K. Rai and B. Kumar, Asian J. Chem., 23, 4635 (2011); B.K. Rai and K.K. Sharma, Orient. J. Chem., 27, 143 (2011).
- A.I. Vogel, Vogel's Text Book of Quantitative Chemical Analysis, Revised by J. Mendham, R.C. Denny, J.D. Barnes and M. Thomas, Pearson Education (2008).
- W. Kemp, Organic Spectroscopy, Polgrave, MacMillan Press Ltd, New York, R.M. Silverstein and F.X. Webster, Spectrometric Identification of Organic Compounds, John Wiley & Sons, edn. 6 (2008).
- J.R. Ferraro, Low Frequency Vibration of Inorganic and Coordination Compound, Plenum Press, New York.
- C.N.R. Rao, Chemical Application of IR Spectroscopy, Academic Press, New York (1963).
- J.A. Wolmsley and S.V. Tyree, Inorg. Chem., 2, 312 (1963); O.N. Sathyanarayn and C.C. Patel, Indian J. Chem., 5, 360 (1967).
- C.J. Bollhausen, Introduction of Ligand Field Theory, McGraw Hill, New York, p. 208 (1962).
- C.C. Addison, N. Logan, S.C. Wallwork and D.C. Barner, Quart. Rev. (1971).
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- R.L. Carlin and A.J. Van Dryneveledt, Magnetic Properties of Transition Metal Compounds, Springer Verlag, New York (1997).
- P.K. Mukherjee, K. Saha, S.N. Giri, M. Pal and B.P. Saha, Indian J. Microbiol., 35, 327 (1995).
References
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A.G.A. El-Helby, Acta Pharm., 53, 127 (2003).
N.M. Raghwendra, P.P. Thampi and P.M. Gurubasavarajswamy, E-J. Chem., 5, 23 (2008).
S.T. Pai and M.W. Platt, Lett. Appl. Microb., 20, 14 (1994).
P.A.J. Janseen, J. Coordiovase Pharmacol., 7, 52 (1985).
D.P. Gupta, S. Ahmad, A. Kumar and K. Shankar, Indian J. Chem., 27B, 1060 (1988).
B.R. Vogt and L.M. Simpkins, Ger. Pat. Offen, 2,916,992 (1979); Chem. Abstr., 92, 111052 (1980).
E. Berenyi, E. Szirt, P. Gorog, L. Petocz, I. Kosoczky, A. Kovacs and G. Urmos, Ger. Pat Offen, 3,0199 (1980); Chem. Abstr., 94, 156963 (1981).
E.J. Alexander, U.S. Pat., 4,105,766 (1976); Chem Abstr., 90, 87505 (1979).
T. Singh, S. Sharma, V. K. Shrivastava and A. Kumar, Indian J. Chem., 45B, 2558 (2006).
S.R. Pattan, V.V.K. Reddy, F.V. Manvi, B.G. Desai and A.R. Bhat, Indian J. Chem., 45B, 1778 (2006).
B.K. Rai and K. Sharma, Asian J. Chem., 20, 137 (2008); B.K. Rai, R. Rai, P. Sahi and S. Rana, Asian J. Chem., 20, 143, 149 (2008).
B.K. Rai, Z. Hussain, U.P. Singh, S.N. Prasad, A. Prasad and P.M. Mishra, Ultra J. Chem., 4, 53 (2008); B.K. Rai and S.N. Prasad, Ultra J. Chem., 4, 71 (2008); B.K. Rai and A. Kumar, Ultra J. Chem.; 4, 179 (2008); B.K. Rai, J. Indian Coun. Chem., 25, 137 (2008); B.K. Rai, A. Baluni, A. Prasad, R. Thakur and P. Prakash, Asian J. Chem., 21, 3708, 3713 (2009).
B.K. Rai and Vinayak, Ultra J. Chem., 5, 67 (2009); B.K. Rai,A. Kumar and Ravishankar, Ultra J. Chem., 5, 73 (2009); B.K. Rai, S. Kumari, R.K. Singh, A. Prasad, M.P. Sinha and P.M. Mishra, Ultra J. Chem., 5, 83 (2009); A. Prasad and B.K. Rai, Orient J. Chem., 25, 175 (2000); B.K. Rai, Ravishankar and S. Pandey, Asian J Chem., 21, 5409, 5994 (2009); B.K. Rai, A. Prasad, Vinayak, A. Kumar and S. Jha 'Sunit', Asian J. Phys., 18, 63 (2009); B.K. Rai, V. Singh, Vinayak, S.P. Singh and S. Jha ‘Sunit’, Asian J. Phys., 18, 67 (2009); B.K. Rai, J. Indian Coun. Chem., 26, 121 (2009); B.K. Rai, Asian J. Chem., 22, 2761 (2010); B.K. Rai and C. Kumar, Asian J. Chem., 22, 5613 (2010); B.K. Rai and S. Singh, Asian J. Chem., 22, 5619 (2010); B.K. Rai and K.K. Sharma, Asian J. Chem., 22, 5625 (2010).
B.K. Rai and R. Kumari, Asian J. Chem., 23, 4625 (2011); B.K. Rai, P. Sinha, S.N. Vidyarathi and V. Singh, Asian J. Chem., 23, 4629 (2011); B.K. Rai, V. Singh, S.N. Vidyarathi and P. Sinha, Asian J. Chem., 23, 4638 (2011); B.K. Rai and B. Kumar, Asian J. Chem., 23, 4635 (2011); B.K. Rai and K.K. Sharma, Orient. J. Chem., 27, 143 (2011).
A.I. Vogel, Vogel's Text Book of Quantitative Chemical Analysis, Revised by J. Mendham, R.C. Denny, J.D. Barnes and M. Thomas, Pearson Education (2008).
W. Kemp, Organic Spectroscopy, Polgrave, MacMillan Press Ltd, New York, R.M. Silverstein and F.X. Webster, Spectrometric Identification of Organic Compounds, John Wiley & Sons, edn. 6 (2008).
J.R. Ferraro, Low Frequency Vibration of Inorganic and Coordination Compound, Plenum Press, New York.
C.N.R. Rao, Chemical Application of IR Spectroscopy, Academic Press, New York (1963).
J.A. Wolmsley and S.V. Tyree, Inorg. Chem., 2, 312 (1963); O.N. Sathyanarayn and C.C. Patel, Indian J. Chem., 5, 360 (1967).
C.J. Bollhausen, Introduction of Ligand Field Theory, McGraw Hill, New York, p. 208 (1962).
C.C. Addison, N. Logan, S.C. Wallwork and D.C. Barner, Quart. Rev. (1971).
A.B.P. Lever, Inorganic Electronics Spectroscopy, Elsevier Amsterdam, p. 395 ( 1968).
B.N. Figgis, Introduction to Ligand Field, Wiley Eastern Ltd., New Delhi, p. 279 (1976).
R.L. Carlin and A.J. Van Dryneveledt, Magnetic Properties of Transition Metal Compounds, Springer Verlag, New York (1997).
P.K. Mukherjee, K. Saha, S.N. Giri, M. Pal and B.P. Saha, Indian J. Microbiol., 35, 327 (1995).