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Vol. 25 No. 2 (2013): Vol 25 Issue 2

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A Facile Route for Synthesis of (±)-Dinoprost, (±)-Carboprost and Its Analogs

https://doi.org/10.14233/ajchem.2013.13139
M. Shankar
Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
H. Rama Mohan
Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
U. Viplava Prasad
Food and Drug Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530 003, India
M. Hari Krishna
Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
P. Mareswar Rao
Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
T. Lakshmikumar
Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
Gottumukkala V. Subbaraju
Lakshmi Surya, A-16, Nalanda Nagar, Tirupati-517 502, India

Corresponding Author(s) : M. Shankar

shankar.m@aptuitlaurus.com

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

A general synthetic approach was developed for (±)-dinoprost (1), (±)-carboprost (2) and their analogs (3-5) through a key intermediate (6). Compound 6 can be converted into the target compounds in two or three steps. Diastereomeric separation was accomplished easily for obtaining (±) dinoprost. Separation of diastereomers was difficult for (±) carboprost and their analogs. Key intermediate 6 was obtained, in turn, from (±)-corey lactone.

Keywords

Corey lactone Dinoprost Carboprost PGF2a analogs
Shankar, M., Rama Mohan, H., Viplava Prasad, U., Hari Krishna, M., Mareswar Rao, P., Lakshmikumar, T., & V. Subbaraju, G. (2012). A Facile Route for Synthesis of (±)-Dinoprost, (±)-Carboprost and Its Analogs. Asian Journal of Chemistry, 25(2), 913–920. https://doi.org/10.14233/ajchem.2013.13139
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