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Vol. 25 No. 2 (2013): Vol 25 Issue 2

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Spectrophotometric Multicomponent Resolution of a Tablet Formulation Containing Lisinopril and Hydrochlorothiazide by Multivariate Calibration Methods

https://doi.org/10.14233/ajchem.2013.13341
Sule Dinç
Department of Chemistry, Faculty of Science and Arts, Yildiz Technical University, Davutpasa Campus, 34220 Istanbul, Turkey
Özlem Aksu Dönmez
Department of Chemistry, Faculty of Science and Arts, Yildiz Technical University, Davutpasa Campus, 34220 Istanbul, Turkey
Bürge Asçi
Department of Chemistry, Faculty of Science and Arts, Yildiz Technical University, Davutpasa Campus, 34220 Istanbul, Turkey
Abdürrezzak E. Bozdogan
Department of Chemistry, Faculty of Science and Arts, Yildiz Technical University, Davutpasa Campus, 34220 Istanbul, Turkey

Corresponding Author(s) : Sule Dinç

sule_dinc@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 2 (2013): Vol 25 Issue 2

Abstract

Partial least squares (PLS), principal components regression (PCR) and multiple linear regression (MLR) methods were used for the determination of lisinopril (LIS) and hydrochlorothiazide in a pharmaceutical formulation. Experimental calibration matrix was constructed using 25 samples, according to multilevel multifactor design.The concentration ranges considered were 4-20 μg mL-1 for lisinopril and 3-11 μg mL-1 for hydrochlorothiazide. The absorbances were recorded between 190 and 400 nm every 1 nm. The validation of the multivariate methods was realized by analyzing the synthetic mixtures of lisinopril and hydrochlorothiazide. These multivariate methods were also applied to the commercial tablet formulations containing lisinopril and hydrochlorothiazide. High performance liquid chromato-graphy method was used as a comparison method. The results obtained were statistically compared with each other.

Keywords

Lisinopril Hydrochlorothiazide Multivariate calibration methods Simultaneous spectrophotometric determination Tablet
Dinç, S., Aksu Dönmez, . Özlem, Asçi , . B. ., & E. Bozdogan, A. . (2012). Spectrophotometric Multicomponent Resolution of a Tablet Formulation Containing Lisinopril and Hydrochlorothiazide by Multivariate Calibration Methods. Asian Journal of Chemistry, 25(2), 999–1002. https://doi.org/10.14233/ajchem.2013.13341
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References
  1. N. Erk, Spectrosc. Lett., 31, 633 (1998).
  2. N. Erk and M. Kartal, Anal. Lett., 32, 1131 (1999).
  3. D. Ivanovic, M. Medenica, B. Jancic, N. Kne•evic, A. Malenovic and J. Milic, Acta Chromatogr., 18, 143 (2007).
  4. A. El-Gindy, A. Ashour, L. Abdel-Fattah and M.M. Shabana, J. Pharm. Biomed. Anal., 25, 923 (2001).
  5. S. Hillaert, K. De Grauwe and W. Van den Bossche, J. Chromatogr. A, 924, 439 (2001).
  6. H. Khajehsharifi, Z. Eskandari and A. Asadipour, Drug Test. Anal., 2, 162 (2010).
  7. A.C. Mot, F. Soponar, A. Medvedovici and C. Sarbu, Anal. Lett., 43, 804 (2010).
  8. A. Samadi-Maybodi and S.K.H. Nejad-Darzi, Spectrochim. Acta A, 75, 1270 (2010).
  9. M. Chamsaz, M.H. Arbabzavar, T. Heidari, A. Hajinia and T. Salehi, Asian J. Chem., 22, 4717 (2010).
  10. R.M. Maggio, P.M. Castellano and T.S. Kaufman, Anal. Bioanal. Chem., 391, 2949 (2008).
  11. E. Dinç, A. Bilgili and B. Hanedan, Pharmazie, 62, 179 (2007).
  12. E. Dinç, M. Kanbur and D. Baleanu, Rev. Chim., 58, 195 (2007).
  13. A.P. do Nascimento, M.G. Trevisan, E.R.M. Kedor-Hackmann and R.J. Poppi, Anal. Lett., 40, 975 (2007).
  14. J. Ghasemi, A. Niazi and S. Ghobadi, J. Chin. Chem. Soc., 52, 1049 (2005).
  15. E. Dinç, Anal. Lett., 35, 1021 (2002).
  16. N. A.El-Ragehy, S.S. Abbas and S. Z. El-Khateeb, Anal. Chim. Acta, 461, 155 (2002).
  17. M.C.F. Ferraro, P.M. Castellano and T.S. Kaufman, J. Pharm. Biomed. Anal., 30, 1121 (2002).
  18. Ö.A. Dönmez, A. Bozdogan, G. Kunt and Y. Div, J. Anal. Chem., 65, 30 (2010).
  19. Ö.A. Dönmez, A. Bozdogan, G. Kunt and Y. Div, Chem. Anal., 52, 135 (2007).
  20. Ö.A. Dönmez, A. Bozdogan and G. Kunt, Rev. Anal. Chem., 26, 209 (2007).
  21. R.G. Brereton, Analyst, 122, 1521 (1997).
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