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Preparation of 2(3H)-Benzimidazolone and its Derivative Under Aqueous Condition As a Potential Agent for Antidiabetic Compounds
Corresponding Author(s) : Muhammad Azhar Abbas
Asian Journal of Chemistry,
Vol. 25 No. 1 (2013): Vol 25 Issue 1
Abstract
A focused library of 2(3H)-benzimidazolone and its derivatives has been synthesized in an attempt to identify their antidiabetic potential. All the products have been synthesized under aqueous conditions in lesser time with better yield and purity. A new effective and convenient method for in situ synthesis of five member heterocyclic ring by reaction of phenylene diamine with urea in solvent phase. All the synthesized compounds were characterized by modern spectroscopic techniques.
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- E. Nicolai, J. Goyard, T. Benchetrit, M. Jean, F. Caussade, A. Virone, Delchambre and A. Chantal, J. Med. Chem., 36, 1175 (1993).
- R.B. Silverman, The Organic Chemistry of Drug Design and Drug Action, Elsevier Academic Press: Oxford, edn. 2 (2004).
- X.n-J. Xu and Y.-X. Zong, Tetrahedron Lett., 48, 129 (2007).
- M.C. McKay, S.I. Dworetzky, N.A. Meanwell, S.-P. Olesen, P.H. Reinhart, I.B. Levitan, J.P. Adelman and V.K. Gribkoff, J. Neurophysiol., 71, 873 (1994).
- German Patent No. 2,905,876.
- R.K. Smalley and T.E. Bingham, J. Chem. Soc. C, 2481 (1969).
- D.W. Wooley, J. Biol. Chem., 152, 225 (1944).
- O. Prakash, H. Batra, H. Kaur, P.K. Sharma, V. Sharma, S.P. Singh and R.M. Moriatry, Synthesis, 541 (2001).
- D.M. Smith and P.M. Preston, Chem. Heterocycl. Comp., 40, 331 (1981).
- M.R. Grimmett, A.R. Katritzky, C.W. Rees and K.T. Potts, Comprehensive Heterocyclic Chemistry, Pergamon Press, Oxford, Ch. 33, p. 2101 (1990)
References
E. Nicolai, J. Goyard, T. Benchetrit, M. Jean, F. Caussade, A. Virone, Delchambre and A. Chantal, J. Med. Chem., 36, 1175 (1993).
R.B. Silverman, The Organic Chemistry of Drug Design and Drug Action, Elsevier Academic Press: Oxford, edn. 2 (2004).
X.n-J. Xu and Y.-X. Zong, Tetrahedron Lett., 48, 129 (2007).
M.C. McKay, S.I. Dworetzky, N.A. Meanwell, S.-P. Olesen, P.H. Reinhart, I.B. Levitan, J.P. Adelman and V.K. Gribkoff, J. Neurophysiol., 71, 873 (1994).
German Patent No. 2,905,876.
R.K. Smalley and T.E. Bingham, J. Chem. Soc. C, 2481 (1969).
D.W. Wooley, J. Biol. Chem., 152, 225 (1944).
O. Prakash, H. Batra, H. Kaur, P.K. Sharma, V. Sharma, S.P. Singh and R.M. Moriatry, Synthesis, 541 (2001).
D.M. Smith and P.M. Preston, Chem. Heterocycl. Comp., 40, 331 (1981).
M.R. Grimmett, A.R. Katritzky, C.W. Rees and K.T. Potts, Comprehensive Heterocyclic Chemistry, Pergamon Press, Oxford, Ch. 33, p. 2101 (1990)