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Application of the Artificial Neural Network and Response Surface Methodology Models for Predicting the Enzymatic Synthesis of Betulinic Acid Ester: A Comparative Study
Corresponding Author(s) : F.B.H. Ahmad
Asian Journal of Chemistry,
Vol. 25 No. 1 (2013): Vol 25 Issue 1
Abstract
In this paper, the estimation capabilities of the response surface methodology and artificial neural network, in an enzymatic reaction catalyzed by Candida antarctica lipase (Novozym 435), were investigated. The experiments were conducted based on a five-level, four-variable central composite rotatable design. The yield of ester in the enzymatic reaction was considered as a function of four independent variables, namely reaction time, reaction temperature, enzyme amount and substrate molar ratio. After predicting the model using response surface methodology and artificial neural network, two methodologies were then compared for their modeling. The results showed that the artificial neural network model is much more accurate in prediction as compared to the response surface methodology.
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- M.M. O'Connel, M.D. Bently, C.S. Campbell and B.J.W. Cole, Photochemistry, 27, 2175 (1988).
- I. Habiyaremye, T. Stevanovic-Janezic, B. Riedl, F.-X. Garneau and F.-I. Jean, J. Wood Chem. Technol., 22, 83 (2001).
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- M. Kvasnica, J. Sarek, E. Klinotova, P. Dzubak and M. Hajduch, Bioorg. Med. Chem., 13, 3447 (2005).
- D.C. Montgomery, Design and Analysis of Experiments, Wiley, New Jersey (2004).
- W.-D. Chiang, S.-W. Chang and C.-J. Shieh, Proc. Biochem., 38, 1193 (2003).
- H.S. Krishna,A.P. Sattur and N.G. Karanth, Proc. Biochem., 37, 9 (2001).
- D. Bas and I.H. Boyaci, J. Food Eng., 78, 836 (2007).
- D. Bas and I.H. Boyaci, J. Food Eng., 78, 846 (2007).
- B. Manohar and S. Divakar, Proc. Biochem., 40, 3372 (2005).
- V.K. Pareek, M.P. Brungs, A.A. Adesina and R. Sharma, J. Photochem. Photobiol. A. Chem., 149, 139 (2002).
- K.M. Desai, S.A. Survase, P.S. Saudagar, S.S. Lele and R.S. Singhal, Biochem. Eng. J., 41, 266 (2008).
- M. Basri, R.R. Zaliha, A. Ebrahimpour, A.B. Salleh, E.R. Gunawan and A. Rahman, BMC Biotechnol., 7, 53 (2007).
- W. Lou and S. Nakai, Food Res. Int., 34, 573 (2001).
- J. Bourquin, H. Schmidli, P.V. Hoogevest and A. Leuenberger, Eur. J. Pharm. Sci., 7, 5 (1998).
- S. Agatonovic-Kustrin, M. Zecevic, L.G. Zivanovic and I.G. Tucker, J. Pharm. Biomed. Anal., 17, 69 (1998).
- F.B.H. Ahmad, J. Omar and A.M. Ali, Ultra Sci., 11, 357 (1999).
- W.G. Cochran and G.M. Cox, Experimental Designs, Wiley, New York (1992).
- CPC-X Software. NeuralPower User Guide. Regsoft Inc. (2004). Available via DIALOG: http://www.geocities.com/neuralpower or http://www. brothersoft.com/neuralpower-download-21356.htmL
- F.B.H. Ahmad, M.G. Moghaddam, M. Basri and M.B. Abdul Rahman, Biocatal. Biotransform., 28, 192 (2010).
- M.G. Moghaddam, F.B.H. Ahmad, M. Basri and M.B.A. Rahman, Elect. J. Biotechnol., 13, 3 (2010).
References
M.M. O'Connel, M.D. Bently, C.S. Campbell and B.J.W. Cole, Photochemistry, 27, 2175 (1988).
I. Habiyaremye, T. Stevanovic-Janezic, B. Riedl, F.-X. Garneau and F.-I. Jean, J. Wood Chem. Technol., 22, 83 (2001).
P. Yogeeswari and D. Sriram, Curr. Med. Chem., 12, 657 (2005).
P.A. Krasutsky, Nat. Prod. Rep., 23, 919 (2006).
M. Kvasnica, J. Sarek, E. Klinotova, P. Dzubak and M. Hajduch, Bioorg. Med. Chem., 13, 3447 (2005).
D.C. Montgomery, Design and Analysis of Experiments, Wiley, New Jersey (2004).
W.-D. Chiang, S.-W. Chang and C.-J. Shieh, Proc. Biochem., 38, 1193 (2003).
H.S. Krishna,A.P. Sattur and N.G. Karanth, Proc. Biochem., 37, 9 (2001).
D. Bas and I.H. Boyaci, J. Food Eng., 78, 836 (2007).
D. Bas and I.H. Boyaci, J. Food Eng., 78, 846 (2007).
B. Manohar and S. Divakar, Proc. Biochem., 40, 3372 (2005).
V.K. Pareek, M.P. Brungs, A.A. Adesina and R. Sharma, J. Photochem. Photobiol. A. Chem., 149, 139 (2002).
K.M. Desai, S.A. Survase, P.S. Saudagar, S.S. Lele and R.S. Singhal, Biochem. Eng. J., 41, 266 (2008).
M. Basri, R.R. Zaliha, A. Ebrahimpour, A.B. Salleh, E.R. Gunawan and A. Rahman, BMC Biotechnol., 7, 53 (2007).
W. Lou and S. Nakai, Food Res. Int., 34, 573 (2001).
J. Bourquin, H. Schmidli, P.V. Hoogevest and A. Leuenberger, Eur. J. Pharm. Sci., 7, 5 (1998).
S. Agatonovic-Kustrin, M. Zecevic, L.G. Zivanovic and I.G. Tucker, J. Pharm. Biomed. Anal., 17, 69 (1998).
F.B.H. Ahmad, J. Omar and A.M. Ali, Ultra Sci., 11, 357 (1999).
W.G. Cochran and G.M. Cox, Experimental Designs, Wiley, New York (1992).
CPC-X Software. NeuralPower User Guide. Regsoft Inc. (2004). Available via DIALOG: http://www.geocities.com/neuralpower or http://www. brothersoft.com/neuralpower-download-21356.htmL
F.B.H. Ahmad, M.G. Moghaddam, M. Basri and M.B. Abdul Rahman, Biocatal. Biotransform., 28, 192 (2010).
M.G. Moghaddam, F.B.H. Ahmad, M. Basri and M.B.A. Rahman, Elect. J. Biotechnol., 13, 3 (2010).