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Vol. 25 No. 1 (2013): Vol 25 Issue 1

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Synthesis and Biological Activity of Some 3-[(4-Amino-5-thioxo-1,2,4-triazol-3-yl)methyl]benzothiazol-2(3H)-one Derivatives

https://doi.org/10.14233/ajchem.2013.12903
Yasemin Dundar
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey
Fatma Kaynak Onurdag
Department of Microbiology, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey
Tijen Önkol
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey

Corresponding Author(s) : Tijen Önkol

tijen@gazi.edu.tr

Asian Journal of Chemistry, Vol. 25 No. 1 (2013): Vol 25 Issue 1

Abstract

Fourteen new 3-[(4-amino-5-thioxo-1,2,4-triazol-3-yl)methyl]benzothiazol-2(3H)-one derivatives have been synthesized. The structures of these compounds were confirmed by IR, 1H NMR, mass spectrum and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates, for their antifungal activity against Candida albicans and C. krusei and for their antimycobacterial activity against M. tuberculosis H37Rv and its clinical isolate. Some of the compounds showed promising activity.

Keywords

Benzothiazol-2(3H)-one 4-Amino-5-thioxo-1,2,4-triazol Antimicrobial Antitubercular
Dundar, Y., Kaynak Onurdag, F., & Önkol, T. (2012). Synthesis and Biological Activity of Some 3-[(4-Amino-5-thioxo-1,2,4-triazol-3-yl)methyl]benzothiazol-2(3H)-one Derivatives. Asian Journal of Chemistry, 25(1), 225–230. https://doi.org/10.14233/ajchem.2013.12903
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