Copyright (c) 2015 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Antibacterial Activity of Coumarin and Its Derivatives
Corresponding Author(s) : Zulfiqar Ali
Asian Journal of Chemistry,
Vol. 27 No. 9 (2015): Vol 27 Issue 9
Abstract
Coumarin and its different derivatives were prepared by treating ethyl acetoacetate with phenol and its different derivatives in acidic media. Product formation was confirmed by spectroscopic techniques i.e. IR, NMR etc. The antimicrobial activities of synthesized compounds were checked against different gram positive and gram negative bacteria by agar ditch method.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- T. Ojala, S. Remes, P. Haansuu, H. Vuorela, R. Hiltunen, K. Haahtela and P. Vuorela, J. Ethnopharmacol., 73, 299 (2000); doi:10.1016/S0378-8741(00)00279-8.
- C.B. Alice, V.M.F. Vargas, G.A.A.B. Silva, N.C.S. de Siqueira, E.E.S. Schapoval, J. Gleye, J.A.P. Henriques and A.T. Henriques, J. Ethnopharmacol., 35, 165 (1991); doi:10.1016/0378-8741(91)90069-P.
- C. Gleye, G. Lewin, A. Laurens, J. Jullian, P. Loiseau, C. Bories and R. Hocquemiller, J. Nat. Prod., 66, 690 (2003); doi:10.1021/np020563j.
- D.A. Egan, R. O’Kennedy, E. Moran, D. Cox, E. Prosser and R.D. Thornes, Drug Metab. Rev., 22, 503 (1990); doi:10.3109/03602539008991449.
- J. Casley Smith and J.I. Coll, Phys. Surg., 22, 67 (1993).
- P. Laurin, D. Ferroud, M. Klich, C. Dupuis-Hamelin, P. Mauvais, P. Lassaigne, A. Bonnefoy and B. Musicki, Bioorg. Med. Chem. Lett., 9, 2079 (1999); doi:10.1016/S0960-894X(99)00329-7.
- J.R.S. Hoult and M. Paya, Gen. Pharmacol., 27, 713 (1996); doi:10.1016/0306-3623(95)02112-4.
- S.P. Pillai, S.R. Menon, L.A. Mitscher, C.A. Pillai and D.A. Shankel, J. Nat. Prod., 62, 1358 (1999); doi:10.1021/np990048u.
- A. Maucher, M. Kager and E. von Angerer, J. Cancer Res. Clin. Oncol., 119, 150 (1993); doi:10.1007/BF01229529.
- S. Sharma, D. Stutzman, J.G. Kellof and V.E. Steele, Cancer Res., 54, 5848 (1994).
- B.M. Reddy, B. Thirupathi and M.K. Patil, The Open Catalysis J., 2, 33 (2009); doi:10.2174/1876214X00902010033.
References
T. Ojala, S. Remes, P. Haansuu, H. Vuorela, R. Hiltunen, K. Haahtela and P. Vuorela, J. Ethnopharmacol., 73, 299 (2000); doi:10.1016/S0378-8741(00)00279-8.
C.B. Alice, V.M.F. Vargas, G.A.A.B. Silva, N.C.S. de Siqueira, E.E.S. Schapoval, J. Gleye, J.A.P. Henriques and A.T. Henriques, J. Ethnopharmacol., 35, 165 (1991); doi:10.1016/0378-8741(91)90069-P.
C. Gleye, G. Lewin, A. Laurens, J. Jullian, P. Loiseau, C. Bories and R. Hocquemiller, J. Nat. Prod., 66, 690 (2003); doi:10.1021/np020563j.
D.A. Egan, R. O’Kennedy, E. Moran, D. Cox, E. Prosser and R.D. Thornes, Drug Metab. Rev., 22, 503 (1990); doi:10.3109/03602539008991449.
J. Casley Smith and J.I. Coll, Phys. Surg., 22, 67 (1993).
P. Laurin, D. Ferroud, M. Klich, C. Dupuis-Hamelin, P. Mauvais, P. Lassaigne, A. Bonnefoy and B. Musicki, Bioorg. Med. Chem. Lett., 9, 2079 (1999); doi:10.1016/S0960-894X(99)00329-7.
J.R.S. Hoult and M. Paya, Gen. Pharmacol., 27, 713 (1996); doi:10.1016/0306-3623(95)02112-4.
S.P. Pillai, S.R. Menon, L.A. Mitscher, C.A. Pillai and D.A. Shankel, J. Nat. Prod., 62, 1358 (1999); doi:10.1021/np990048u.
A. Maucher, M. Kager and E. von Angerer, J. Cancer Res. Clin. Oncol., 119, 150 (1993); doi:10.1007/BF01229529.
S. Sharma, D. Stutzman, J.G. Kellof and V.E. Steele, Cancer Res., 54, 5848 (1994).
B.M. Reddy, B. Thirupathi and M.K. Patil, The Open Catalysis J., 2, 33 (2009); doi:10.2174/1876214X00902010033.