A New Anthraquinones from Cassia fistula and its Cytotoxicity

Lan Li; Wen-Xiu Xu; Chun-Bo Liu; Cheng-Ming Zhang; Wei Zhao; Shan-Zhai Shang; Liang Deng; Ya-Dong Guo

doi:10.14233/ajchem.2015.18662

Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

Issue Published : May 26, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Anthraquinones from Cassia fistula and its Cytotoxicity

https://doi.org/10.14233/ajchem.2015.18662

Lan Li

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, P.R. China; Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, P.R. China

Wen-Xiu Xu

Chun-Bo Liu

Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, P.R. China

Cheng-Ming Zhang

Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, P.R. China

Wei Zhao

Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, P.R. China

Shan-Zhai Shang

Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, P.R. China

Liang Deng

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, P.R. China

Ya-Dong Guo

School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, P.R. China

Corresponding Author(s) : Liang Deng

yadongkmmc@163.com; ygy1110@163.com

Asian Journal of Chemistry, Vol. 27 No. 9 (2015): Vol 27 Issue 9
Article Published : May 26, 2015

Abstract

A new anthraquinone, cassiquinone A (1), was isolated from the stems of Cassia fistula. Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 1 was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and compound 1 showed high cytotoxicity against A549 and MCF7 cell with IC₅₀ values of 8.2 and 6.5 μM, respectively.

Keywords

Anthraquinone Cassia fistula Cytotoxicity

Li, L., Xu, W.-X., Liu, C.-B., Zhang, C.-M., Zhao, W., Shang, S.-Z., … Guo, Y.-D. (2015). A New Anthraquinones from Cassia fistula and its Cytotoxicity. Asian Journal of Chemistry, 27(9), 3527–3528. https://doi.org/10.14233/ajchem.2015.18662

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Issue

Vol. 27 No. 9 (2015): Vol 27 Issue 9

A New Anthraquinones from Cassia fistula and its Cytotoxicity

Corresponding Author(s) : Liang Deng

Abstract

Keywords

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