A New Benzofuran Derivatives from Flue-Cured Tobacco and Its Anti-Tobacco Mosaic Virus Activity

Chunbo Liu; Qinpeng Shen; Fengmei Zhang; Tao Zhang; Pei He; Ruizhi Zhu; Kunmiao Wang; Zhihua Liu; Guangyu Yang; Zhangyu Chen

doi:10.14233/ajchem.2015.18009

Issue

Vol. 27 No. 8 (2015): Vol 27 Issue 8

Issue Published : April 27, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Benzofuran Derivatives from Flue-Cured Tobacco and Its Anti-Tobacco Mosaic Virus Activity

https://doi.org/10.14233/ajchem.2015.18009

Chunbo Liu

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Qinpeng Shen

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Fengmei Zhang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Tao Zhang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Pei He

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Ruizhi Zhu

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Kunmiao Wang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Zhihua Liu

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Guangyu Yang

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Zhangyu Chen

Key Laboratory of Tobacco Chemistry of Yunnan Province, Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, P.R. China

Corresponding Author(s) : Zhangyu Chen

ygy1110@163.com

Asian Journal of Chemistry, Vol. 27 No. 8 (2015): Vol 27 Issue 8
Article Published : April 27, 2015

Abstract

A new benzofuran derivative, (2S,3R,4R)-3,4-dihydroxy-2,7-dimethoxy-3,4-dihydro-1(2H)- dibenzofuranone (1), was isolated from the leaves of flue-cured tobacco (a variety of Nicotiana tabacum L). Its structure was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was also tested for its anti-tobacco mosaic virus activity and it shows potential anti-tobacco mosaic virus activity with inhibition rates of 42.3 %.

Keywords

Benzofuran derivative Flue-cured tobacco Mosaic virus activity

Liu, C., Shen, Q., Zhang, F., Zhang, T., He, P., Zhu, R., … Chen, Z. (2015). A New Benzofuran Derivatives from Flue-Cured Tobacco and Its Anti-Tobacco Mosaic Virus Activity. Asian Journal of Chemistry, 27(8), 2753–2755. https://doi.org/10.14233/ajchem.2015.18009

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The Editorial Committee of the Administration Bureau of Flora of China, Flora of China, 67 vols, Beijing Science and Technology Press, Beijing (2005).

T.W. Hu and Z. Mao, Tob. Control, 15(suppl_1), i37 (2006); doi:10.1136/tc.2005.014621.

A. Rodgman and T.A. Perfetti, The Chemical Components of Tobacco and Tobacco Smoke. CRC Press, Taylor and Francis Group, Boca Raton, Florida (2008).

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A. Inta, P. Shengji, H. Balslev, P. Wangpakapattanawong and C. Trisonthi, J. Ethnopharmacol., 116, 134 (2008); doi:10.1016/j.jep.2007.12.015.

X. Feng, J.S. Wang, J. Luo and L.Y. Kong, J. Asian Nat. Prod. Res., 12, 252 (2010); doi:10.1080/10286020903550947.

Y. Shinozaki, T. Tobita, M. Mizutani and T. Matsuzaki, Biosci. Biotechnol. Biochem., 60, 903 (1996); doi:10.1271/bbb.60.903.

T. Pettersson, A.M. Eklund and I. Wahlberg, J. Agric. Food Chem., 41, 2097 (1993); doi:10.1021/jf00035a052.

X.C. Wei, S.C. Sumithran, A.G. Deaciuc, H.R. Burton, L.P. Bush, L.P. Dwoskin and P.A. Crooks, Life Sci., 78, 495 (2005); doi:10.1016/j.lfs.2005.09.009.

T. Braumann, G. Nicolaus, W. Hahn and H. Elmenhorst, Phytochemistry, 29, 3693 (1990); doi:10.1016/0031-9422(90)85311-3.

Y.K. Chen, X.S. Li, G.Y. Yang, Z.Y. Chen, Q.F. Hu and M.M. Miao, J. Asian Nat. Prod. Res., 14, 450 (2012); doi:10.1080/10286020.2012.669578.

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Z.Y. Chen, J.L. Tan, G.Y. Yang, M.M. Miao, Z.Y. Chen and T.F. Li, Phytochem. Lett., 5, 233 (2012); doi:10.1016/j.phytol.2012.01.001.

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Y. Liu, M. Kubo and Y. Fukuyama, J. Nat. Prod., 75, 2152 (2012); doi:10.1021/np300566y.

M. Koreeda, N. Harada and K. Nakanishi, J. Am. Chem. Soc., 96, 266 (1974); doi:10.1021/ja00808a053.

C.L. Cardoso, V.S. Bolzani, D.H.S. Silva, H. Ishii, N. Berova and K. Nakanishi, J. Nat. Prod., 69, 1046 (2006); doi:10.1021/np050522y.

Q.F. Hu, B. Zhou, X.M. Gao, L.Y. Yang, L.D. Shu, Y.Q. Shen, G.P. Li, C.T. Che and G.Y. Yang, J. Nat. Prod., 75, 1909 (2012); doi:10.1021/np300395m.

Issue

Vol. 27 No. 8 (2015): Vol 27 Issue 8

A New Benzofuran Derivatives from Flue-Cured Tobacco and Its Anti-Tobacco Mosaic Virus Activity

Corresponding Author(s) : Zhangyu Chen

Abstract

Keywords

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