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Synthesis and Evaluation of Antibacterial and Antitumor Activities of Apigenin Derivatives
Corresponding Author(s) : Qi-Yong Huai
Asian Journal of Chemistry,
Vol. 27 No. 8 (2015): Vol 27 Issue 8
Abstract
Using nicotinic acid, isonicotinic acid reacted with apigenin via DCC condensation to produce apigenin derivatives. Their chemical structure was confirmed by MS and 1H NMR spectroscopy. The antimicrobial activities of the new compounds and raw materials were explored with Staphylococcus aureus and Acinetobacter. while the antitumor activities of the new compounds and raw materials were explored with SH-SY5Y, MCF-7, HepG2 under the same conditions. The results show that apigenin derivatives have stronger antibacterial properties on Acinetobacter than Staphylococcus. The new compounds have the strongest antitumor activities on HepG2, followed by MCF-7 and relative weak activities on SH-SY5Y in vitro.
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- W. Wang, W.F. Li and Y.Q. Yang, Chemical Agent, 30, 185 (2008)
- L.M. Cintas and J.M. Rodriguez, Appl. Environ. Microbiol., 61, 2643 (1995).
References
P.W. Zheng, L.C. Chiang and C.C. Lin, Life Sci., 76, 1367 (2005); doi:10.1016/j.lfs.2004.08.023.
J. Cyzy, Z. Madija, U. Irmer, W. Korohoda and D.F. Holser, Int. J. Cancer, 114, 12 (2005); doi:10.1002/ijc.20620.
W. Wang, L. Heideman, C.S. Chung, J.C. Pelling, K.J. Koehler and D.F. Birt, Mol. Carcinog., 28, 102 (2000); doi:10.1002/1098-2744(200006)28:2<102::AID-MC6>3.0.CO;2-2.
G. Ferretti, A. Felici, P. Papaldo, A. Fabi and F. Cognetti, Curr. Opin. Obstet. Gynecol., 19, 56 (2007); doi:10.1097/GCO.0b013e328012980a.
G.R. Bekticj, Maturitas, 55, s372 (2006).
W. Wang, W.F. Li and Y.Q. Yang, Chemical Agent, 30, 185 (2008)
L.M. Cintas and J.M. Rodriguez, Appl. Environ. Microbiol., 61, 2643 (1995).