Enantioseparation of Pharmaceuticals by Capillary Electrophoresis Using Per-(6-sulfo-6-deoxy)-b-Cyclodextrin as Chiral Selector

Xinxiu Wang; Yong Fan; Yanjun Zhuang; Liqiang Luo; Tianlin Wang

doi:10.14233/ajchem.2015.18327

Issue

Vol. 27 No. 8 (2015): Vol 27 Issue 8

Issue Published : April 27, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Enantioseparation of Pharmaceuticals by Capillary Electrophoresis Using Per-(6-sulfo-6-deoxy)-b-Cyclodextrin as Chiral Selector

https://doi.org/10.14233/ajchem.2015.18327

Xinxiu Wang

Department of Chemistry, Shanghai University, Shanghai 200444, P.R. China

Yong Fan

Department of Chemistry, Shanghai University, Shanghai 200444, P.R. China

Yanjun Zhuang

Department of Chemistry, Shanghai University, Shanghai 200444, P.R. China

Liqiang Luo

Department of Chemistry, Shanghai University, Shanghai 200444, P.R. China

Tianlin Wang

Department of Chemistry, Shanghai University, Shanghai 200444, P.R. China

Corresponding Author(s) : Tianlin Wang

wtl2404@aliyun.com

Asian Journal of Chemistry, Vol. 27 No. 8 (2015): Vol 27 Issue 8
Article Published : April 27, 2015

Abstract

Four pairs of model enantiomers with different functional groups, phenylalanine, 1-phenylethanol, chlorpheniramine and promethazine, were separated by capillary electrophoresis using negative charged per-(6-sulfo-6-deoxy)-b-cyclodextrin as chiral selector. Baseline resolutions were achieved for all of the enantiomers under the optimal conditions of buffer pH, buffer concentration, per-(6-sulfo-6-deoxy)-b-cyclodextrin concentration and applied voltage.

Keywords

Chiral separation Enantiomer Capillary electrophoresis Sulfonated βββ-cyclodextrin

Wang, X., Fan, Y., Zhuang, Y., Luo, L., & Wang, T. (2015). Enantioseparation of Pharmaceuticals by Capillary Electrophoresis Using Per-(6-sulfo-6-deoxy)-b-Cyclodextrin as Chiral Selector. Asian Journal of Chemistry, 27(8), 2951–2954. https://doi.org/10.14233/ajchem.2015.18327

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References

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References

F. Liu, M. Qiu and S.D. Zhai, Curr. Ther. Res., 71, 1 (2010); doi:10.1016/j.curtheres.2010.02.005.

F.D.A. Policy, Statement for the Development of New Stereoisomeric Drugs, US Food and Drug Administration, 1992. http://www.fda.gov/drugs/guidance- complianceregulatoryinformation/guidances/ucm122883.htm (accessed Jan 2014).

E.R. Francotte, J. Chromatogr. A, 906, 379 (2001); doi:10.1016/S0021-9673(00)00951-1.

A.A. Younes, D. Mangelings and Y. Van der Heyden, J. Chromatogr. A, 1269, 154 (2012); doi:10.1016/j.chroma.2012.07.070.

G. Gübitz and M.G. Schmid, J. Chromatogr. A, 1204, 140 (2008); doi:10.1016/j.chroma.2008.07.071.

J. Szejtli, Chem. Rev., 98, 1743 (1998); doi:10.1021/cr970022c.

K.A. Connors, Chem. Rev., 97, 1325 (1997); doi:10.1021/cr960371r.

T.J. Ward, Anal. Chem, 66, 632A (1994).

S. Cladrowa-Runge and A. Rizzi, J. Chromatogr. A, 759, 167 (1997); doi:10.1016/S0021-9673(96)00761-3.

C. Foulon, C. Danel, M.P. Vaccher, J.P. Bonte, C. Vaccher and J.F. Goossens, Electrophoresis, 25, 2735 (2004); doi:10.1002/elps.200405903.

C. Sänger van de Griend, Electrophoresis, 20, 3417 (1999); doi:10.1002/(SICI)1522-2683(19991101)20:17<3417::AID-ELPS3417>3.0.CO;2-J.

P. Mikuš, I. Valášková and E. Havránek, J. Pharm. Biomed. Anal., 38, 442 (2005); doi:10.1016/j.jpba.2005.01.020.

J. Boonleang and J.F. Stobaugh, Electrophoresis, 34, 1232 (2013); doi:10.1002/elps.201200591.

K. Lomsadze, E.D. Vega, A. Salgado, A.L. Crego, G.K.E. Scriba, M.L. Marina and B. Chankvetadze, Electrophoresis, 33, 1637 (2012); doi:10.1002/elps.201200062.

J. Zhou, F. Ai, B.J. Zhou, J. Tang, S.C. Ng and W.H. Tang, Anal. Chim. Acta, 800, 95 (2013); doi:10.1016/j.aca.2013.09.021.

Y. Dai, S.Y. Wang, J. Zhou, J. Tang and W.H. Tang, Electrophoresis, 34, 833 (2013); doi:10.1002/elps.201200473.

S.Y. Wang, Y. Dai, J.H. Wu, J. Zhou, J. Tang and W.H. Tang, J. Chromatogr. A, 1277, 84 (2013); doi:10.1016/j.chroma.2012.12.045.

M. Novotny, H. Soini and M. Stefansson, Anal. Chem., 66, 646A (1994).

S.A.C. Wren and R.C. Rowe, J. Chromatogr. A, 603, 235 (1992); doi:10.1016/0021-9673(92)85366-2.

Issue

Vol. 27 No. 8 (2015): Vol 27 Issue 8

Enantioseparation of Pharmaceuticals by Capillary Electrophoresis Using Per-(6-sulfo-6-deoxy)-b-Cyclodextrin as Chiral Selector

Corresponding Author(s) : Tianlin Wang

Abstract

Keywords

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