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Spectrophotometric Determination of Fingolimod in Pharmaceutical Dosage Forms
Corresponding Author(s) : Effat Souri
Asian Journal of Chemistry,
Vol. 31 No. 1 (2019): Vol 31 Issue 1
Abstract
Two rapid and simple spectrophotometric methods were proposed for the determination of fingolimod in pharmaceutical dosage forms. In the direct spectrophotometric method, the absorbance of fingolimod was measured at 217 nm. The method was linear over the concentration range of 0.25-30 μg/mL. The second procedure depends on the absorption measurement of an ion-pair complex of fingolimod and fluorescein formed in acidic medium. The second method was also linear over the concentration range of 3-150 μg/mL. Both methods showed acceptable within-day and between-day precision and accuracy (CV < 2 % and error < 2 %). The validated methods were applied successfully for the determination of fingolimod in capsules without any special pre-treatment.
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- R.K. Narasimha, Ch.V.S. Nagaraju, S.T. Rajan, S. Eshwaraiah, G.S.K. Reddy, M. Rakesh, P.S. Rama Sarma, M. Kishore and I.E. Chakravarthy, Der Pharma Chem., 6, 335 (2014).
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References
B.A. Brown, P.P. Kantesaria and L.M. McDevitt, Ann. Pharmacother., 41, 1660 (2007); https://doi.org/10.1345/aph.1G424.
H. Tedesco-Silva, P. Szakaly, A. Shoker, C. Sommerer, N. Yoshimura, F.P. Schena, M. Cremer, A. Hmissi, H. Mayer and P. Lang, Transplantation, 84, 885 (2007); https://doi.org/10.1097/01.tp.0000281385.26500.3b.
V. Brinkmann, M.D. Davis, C.E. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, P. Hiestand, C.A. Foster, M. Zollinger and K.R. Lynch, J. Biol. Chem., 277, 21453 (2002); https://doi.org/10.1074/jbc.C200176200.
K. Chiba, Pharmacol. Ther., 108, 308 (2005); https://doi.org/10.1016/j.pharmthera.2005.05.002.
P. Salm, C.R. Warnholtz, S.V. Lynch and P.J. Taylor, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 843, 157 (2006); https://doi.org/10.1016/j.jchromb.2006.05.026.
M. Zollinger, H.-P. Gschwind, Y. Jin, C. Sayer, F. Zecri and S. Hartmann, Drug Metab. Dispos., 39, 199 (2011); https://doi.org/10.1124/dmd.110.035907.
N. Ferreiros, S. Labocha, M. Schroder, H.H. Radeke and G. Geisslinger, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 887-888, 122 (2012); https://doi.org/10.1016/j.jchromb.2012.01.023.
C. Emotte, F. Deglave, O. Heudi, F. Picard and O. Kretz, J. Pharm. Biomed. Anal., 58, 102 (2012); https://doi.org/10.1016/j.jpba.2011.09.021.
P.J. Chhabda, M. Balaji and V. Srinivasara, Pharmanest, 4, 1206 (2013).
R.K. Narasimha, Ch.V.S. Nagaraju, S.T. Rajan, S. Eshwaraiah, G.S.K. Reddy, M. Rakesh, P.S. Rama Sarma, M. Kishore and I.E. Chakravarthy, Der Pharma Chem., 6, 335 (2014).
E. Souri, M. Zargarpoor, S. Mottaghi, R. Ahmadkhaniha and A. Kebriaeezadeh, Sci. Pharm., 83, 85 (2015); https://doi.org/10.3797/scipharm.1408-08.
S. Ghosh, V.L. Prasanna, B. Sowjanya and D. Banji, Asian J. Res. Chem., 7, 55 (2014).