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Solubility Behaviour of Baicalin in Polar and Non-Polar Solvents: Solubility Parameters Approach
Corresponding Author(s) : Sen Wang
Asian Journal of Chemistry,
Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015
Abstract
The solubility behaviour of baicalin in individual solvents ranging from non-polar to highly polar solvents was evaluated and the results were analyzed in the light of existing systems of data analysis with reference to solubility parameters. Hildbrand approach, extended Hansen's approach, four solubility parameters approach were used to analyze the solubility data and obtain partial solubility parameters of baicalin. Flory-Huggin's size connection term 'B' was found to further improve the value of regression equations. The solubility behaviour regression equations of baicalin were obtained by different approaches, such as ideal solubility model and non-ideal solubility model by Hildbrand solubiliy approach, activity coefficient and 'B' models by extended Hansen's approach and four dimensional solubility parameters approach respectively. The total solubility parameter of baicalin may be in the range of 27.79-33.29 (J/cm3)1/2. Different approaches were used in fitting the experimental solubility data to obtain regression equations which aim to provide a reasonable prediction of solubility of baicalin in untested solvents based on the theory of solubility parameters.
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- B.C. Hancock, P. York and R.C. Rowe, Int. J. Pharm., 148, 1 (1997); doi:10.1016/S0378-5173(96)04828-4.
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- D.S. Su and S.L. Wang, Physical Pharmacy, Chemical Industry Press, Beijing, pp. 53-72 (2004).
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- A.F.M. Barton, Handbook of Solubility Parameter and Other Cohesion Parameters, CRC, Boca Raton, pp. 85-86 (1983).
- A. Beerbower, P.L. Wu and A. Martin, J. Pharm. Sci., 73, 179 (1984); doi:10.1002/jps.2600730210.
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References
B.C. Hancock, P. York and R.C. Rowe, Int. J. Pharm., 148, 1 (1997); doi:10.1016/S0378-5173(96)04828-4.
X.L. Zhi, C.Y. Li, H.Y. Li and G.P. Peng, Asian J. Chem., 25, 8821 (2013); doi:10.14233/ajchem.2013.15749.
H. Wang, J.M. Chen and Q.M. Zhang, J. Shenyang Pharm. Univ., 17, 105 (2000).
X.S. Liu, Y.S. Chen, T.S. Qiu, Y. Chen and L.-H. Wang, J. Chem. Eng. Data, 54, 2330 (2009); doi:10.1021/je900171g.
S.P. Ou, S. Wang and H.Y. Zhang, Progr. Modern Biomed., 9, 3954 (2009).
J.H. Hildebrand and R.L. Scott, The Solubility of Non-electrolytes, Dover, New York, edn. 3 (1964).
D.Z. Liu and Z.Q. Wang, Solubility Parameters and its Application in Coating Industry, China Ocean Press, Beijing, pp. 37-119 (2008).
D.S. Su and S.L. Wang, Physical Pharmacy, Chemical Industry Press, Beijing, pp. 53-72 (2004).
C. Hansen, Hansen Solubility Parameters, A User's Handbook, CRC, Boca Raton, edn 2 (2007).
E. Stefanis and C. Panayiotou, Int. J. Thermophys., 29, 568 (2008); doi:10.1007/s10765-008-0415-z.
S. Abbott, C. Hansen and H. Yamamoto, HSPiP: Hansen Solubility Parameters in Practice, http://hansen-solubility.com/index.php?id=12.
A. Martin, P.L. Wu, A. Adjei, A. Beerbower and J.M. Prausnitz, J. Pharm. Sci., 70, 1260 (1981); doi:10.1002/jps.2600701120.
A.F.M. Barton, Handbook of Solubility Parameter and Other Cohesion Parameters, CRC, Boca Raton, pp. 85-86 (1983).
A. Beerbower, P.L. Wu and A. Martin, J. Pharm. Sci., 73, 179 (1984); doi:10.1002/jps.2600730210.
B.L. Karger, L.R. Snyder and C. Eon, J. Chromatogr. A, 125, 71 (1976); doi:10.1016/S0021-9673(00)93812-3.
J. Thimmasetty, C. Subrahmanyam, P.S. Babu, M.A. Maulik and B.A. Viswanath, J. Solution Chem., 37, 1365 (2008); doi:10.1007/s10953-008-9317-8.