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Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

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Synthesis and Characterization of 4-Amino-quinazoline Derivatives

https://doi.org/10.14233/ajchem.2015.17919
He-Ping Yan
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China
Bo Zhou
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China
Gao-Zhang Gou
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China
Ju-Cheng Zhang
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China
Shi-Juan Xu
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China
Wei Liu
College of Science, Honghe University, Mengzi, Yunnan 661199, P.R. China; Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, Honghe University, Mengzi, Yunnan 661199, P.R. China

Corresponding Author(s) : Ju-Cheng Zhang

yhpyhl9511@163.com

Asian Journal of Chemistry, Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

Abstract

Four 4-amino-quinazoline compounds, including 7-[3-(2-methoxyphenoxy)propoxy]-N'-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-[3-(4-methoxyphenoxy)propoxy]-N'-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 2-[3-{4-(3-chlorophenylamino)-6-methoxy-quinazolin-7-yloxy}propoxy]benzaldehyde, 4-[3-{4-(3-chlorophenylamino)-6-methoxyquinazolin-7-yloxy}propoxy]benzaldehyde, were synthesized from N'-[5-(3-chloropropoxy)-2-cyano-4-methoxyphen-yl]-N,N-dimethylformamidine by cyclization and etheration. The yields of the compounds IIIa-d were 70.3, 71.0, 45.5 and 50.2 %, respectively. Their structures were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis.

Keywords

4-Amino-quinazoline Quinazoline derivatives
Yan, H.-P., Zhou, B., Gou, G.-Z., Zhang, J.-C., Xu, S.-J., & Liu, W. (2015). Synthesis and Characterization of 4-Amino-quinazoline Derivatives. Asian Journal of Chemistry, 27(7), 2460–2462. https://doi.org/10.14233/ajchem.2015.17919
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