Copyright (c) 2015 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
A New Biphenyl from Garcinia oligantha and Its Cytotoxicity
Corresponding Author(s) : Xuemei Gao
Asian Journal of Chemistry,
Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015
Abstract
A new biphenyl i.e., 3-methoxy-5-methoxycarbonyl-4-hydroxy-biphenyl (1) was isolated from the stems of Garcinia oligantha. Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR. This biphenyl was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed modest cytotoxicity against SHSY5Y, A549 and MCF7 cell with IC50 values of 7.1, 6.2 and 4.8 μM, respectively.
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- D. Obolskiy, I. Pischel, N. Siriwatanametanon and M. Heinrich, Phytother. Res., 23, 1047 (2009); doi:10.1002/ptr.2730.
- X.M. Gao, T. Yu, F. Lai, Y. Zhou, X. Liu, C.F. Qiao, J.Z. Song, S.L. Chen, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 18, 4957 (2010); doi:10.1016/j.bmc.2010.06.014.
- X.-M. Gao, T. Yu, F.S.F. Lai, J.-X. Pu, C.-F. Qiao, Y. Zhou, X. Liu, J.-Z. Song, K.Q. Luo and H.-X. Xu, Tetrahedron Lett., 51, 2442 (2010); doi:10.1016/j.tetlet.2010.02.147.
- X. Liu, T. Yu, X.M. Gao, Y. Zhou, C.F. Qiao, Y. Peng, S.L. Chen, K.Q. Luo and H.X. Xu, J. Nat. Prod., 73, 1355 (2010); doi:10.1021/np100156w.
- X.M. Gao, T. Yu, M.Z. Cui, J.X. Pu, X. Du, Q. Han, Q. Hu, T.-C. Liu, K.Q. Luo and H.-X. Xu, Bioorg. Med. Chem., 22, 2350 (2012); doi:10.1016/j.bmcl.2012.01.068.
- H.Y. Yang, Y.H. Gao, D.Y. Niu, L.Y. Yang, X.M. Gao, G. Du and Q.F. Hu, Fitoterapia, 91, 189 (2013); doi:10.1016/j.fitote.2013.09.004.
- V. Rukachaisirikul, K. Tadpetch, A. Watthanaphanit, N. Saengsanae and S. Phongpaichit, J. Nat. Prod., 68, 1218 (2005); doi:10.1021/np058050a.
- K.H. Kim, S.U. Choi, S.K. Ha, S.Y. Kim and K.R. Lee, J. Nat. Prod., 72, 2061 (2009); doi:10.1021/np900460j.
- X.-M. Gao, M.-Z. Cui, T. Yu, Q.-F. Hu, J.-X. Pu, X. Du, T.-C. Liu and K.Q. Luo, Helv. Chim. Acta, 96, 494 (2013); doi:10.1002/hlca.201200245.
- Q. Hu, X. Gao, D. Niu, X. Li, Y. Qin, Z. Yang, G. Zhao, Z. Yang and Z. Chen, Heterocycles, 87, 1127 (2013); doi:10.3987/COM-13-12713.
- X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.
References
D. Obolskiy, I. Pischel, N. Siriwatanametanon and M. Heinrich, Phytother. Res., 23, 1047 (2009); doi:10.1002/ptr.2730.
X.M. Gao, T. Yu, F. Lai, Y. Zhou, X. Liu, C.F. Qiao, J.Z. Song, S.L. Chen, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 18, 4957 (2010); doi:10.1016/j.bmc.2010.06.014.
X.-M. Gao, T. Yu, F.S.F. Lai, J.-X. Pu, C.-F. Qiao, Y. Zhou, X. Liu, J.-Z. Song, K.Q. Luo and H.-X. Xu, Tetrahedron Lett., 51, 2442 (2010); doi:10.1016/j.tetlet.2010.02.147.
X. Liu, T. Yu, X.M. Gao, Y. Zhou, C.F. Qiao, Y. Peng, S.L. Chen, K.Q. Luo and H.X. Xu, J. Nat. Prod., 73, 1355 (2010); doi:10.1021/np100156w.
X.M. Gao, T. Yu, M.Z. Cui, J.X. Pu, X. Du, Q. Han, Q. Hu, T.-C. Liu, K.Q. Luo and H.-X. Xu, Bioorg. Med. Chem., 22, 2350 (2012); doi:10.1016/j.bmcl.2012.01.068.
H.Y. Yang, Y.H. Gao, D.Y. Niu, L.Y. Yang, X.M. Gao, G. Du and Q.F. Hu, Fitoterapia, 91, 189 (2013); doi:10.1016/j.fitote.2013.09.004.
V. Rukachaisirikul, K. Tadpetch, A. Watthanaphanit, N. Saengsanae and S. Phongpaichit, J. Nat. Prod., 68, 1218 (2005); doi:10.1021/np058050a.
K.H. Kim, S.U. Choi, S.K. Ha, S.Y. Kim and K.R. Lee, J. Nat. Prod., 72, 2061 (2009); doi:10.1021/np900460j.
X.-M. Gao, M.-Z. Cui, T. Yu, Q.-F. Hu, J.-X. Pu, X. Du, T.-C. Liu and K.Q. Luo, Helv. Chim. Acta, 96, 494 (2013); doi:10.1002/hlca.201200245.
Q. Hu, X. Gao, D. Niu, X. Li, Y. Qin, Z. Yang, G. Zhao, Z. Yang and Z. Chen, Heterocycles, 87, 1127 (2013); doi:10.3987/COM-13-12713.
X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.