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Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

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Catalyst-Free Synthesis of Quinoxalines

https://doi.org/10.14233/ajchem.2015.18680
Dongming Lu
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Qinjie Xiang
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Lihong Zhou
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Qingle Zeng
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China

Corresponding Author(s) : Qingle Zeng

qinglezeng@hotmail.com

Asian Journal of Chemistry, Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

Abstract

Quinoxalines are a class of important heterocycles, so to explore a facile and practical new synthetic method is always demanded. We have developed a new catalyst-free domino synthesis of quinoxalines from phenacyl halides and 1,2-diaminoarenes. Phenacyl chlorides with lower activities are first used in synthesis of quinoxalines and afford up to 97 % yield with our protocol. Our process with sodium bicarbonate as deacid reagent is catalyst-free, simple, greener and practical.

Keywords

Quinoxalines Domino synthesis Phenacyl halides 1 2-Diaminoarenes Heterocycles
Lu, D., Xiang, Q., Zhou, L., & Zeng, Q. (2015). Catalyst-Free Synthesis of Quinoxalines. Asian Journal of Chemistry, 27(7), 2639–2641. https://doi.org/10.14233/ajchem.2015.18680
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