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Formulation and Evaluation of Hyoscine Butylbromide Parenteral Dosage Form
Corresponding Author(s) : N. Anusha
Asian Journal of Chemistry,
Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015
Abstract
A cost-effective, stable and efficacious parenteral formulation of hyoscine butylbromide, a quaternary ammonium derivative with antimuscarinic and anticholinergic activity used to relieve smooth-muscle spasm in gastro-intestinal and genito-urinary disorders, has been developed in the present study. This expensive drug is unstable in the presence of moisture, light and heat. We have investigated effect of temperature, light, pH and oxygen on the stability of drug. The drug was made into single dose-small volume injectable formulation for administration via intravenous. Formulation trails were carried out in different combinations of different buffers and excipients. Out of all the trials, the best optimized formulations which showed better stability as well as efficacy and which passed all tests satisfactorily when subjected to accelerated stability testing were finalized as commercially viable formulation.
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- G. Grynkiewicz and M. Gadzikowska, Pharmacol. Rep., 60, 439 (2008).
- P. Bhattacharya and S.G. Joshi, J. Obstet. Gynaecol. India, 7, 1014 (1985).
- K. Davenport, A. Timoney and F. Keeley, BJU Int., 95, 297 (2005); doi:10.1111/j.1464-410X.2005.05286.x.
- L.A. Samuels, Clin. Med. Therap., 1, 647 (2009).
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- http://en.wikipedia.org/wiki/Butylscopolamine.
- K.E. Avis, L. Lachman and H.A. Lieberman, Pharmaceutical Dosage Forms: Parenteral Medications, Marcel Dekker, Inc., New York, pp. 112-12 (1984).
- Anonymous, Indian Pharmacopoeia 2010, The Indian Pharmacopoeia Commission, Ghaziabad, India, vol. 2, pp. 1466-1467 (2010).
- Anonymous, Indian Pharmacopoeia 2010, The Indian Pharmacopoeia Commission, Ghaziabad, India, vol. 2, pp. 746-748 (2010).
- N. Vora and V. Anand, Int. J. Pharm. Technol., 4, 2000 (2012).
References
G. Grynkiewicz and M. Gadzikowska, Pharmacol. Rep., 60, 439 (2008).
P. Bhattacharya and S.G. Joshi, J. Obstet. Gynaecol. India, 7, 1014 (1985).
K. Davenport, A. Timoney and F. Keeley, BJU Int., 95, 297 (2005); doi:10.1111/j.1464-410X.2005.05286.x.
L.A. Samuels, Clin. Med. Therap., 1, 647 (2009).
G.N. Tytgat, Curr. Med. Res. Opin., 24, 3159 (2008); doi:10.1185/03007990802472700.
http://en.wikipedia.org/wiki/Butylscopolamine.
K.E. Avis, L. Lachman and H.A. Lieberman, Pharmaceutical Dosage Forms: Parenteral Medications, Marcel Dekker, Inc., New York, pp. 112-12 (1984).
Anonymous, Indian Pharmacopoeia 2010, The Indian Pharmacopoeia Commission, Ghaziabad, India, vol. 2, pp. 1466-1467 (2010).
Anonymous, Indian Pharmacopoeia 2010, The Indian Pharmacopoeia Commission, Ghaziabad, India, vol. 2, pp. 746-748 (2010).
N. Vora and V. Anand, Int. J. Pharm. Technol., 4, 2000 (2012).