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Kinetic and Thermodynamic Properties of Biochanin A in Dimethyl Sulfoxide
Corresponding Author(s) : W.W. Zhao
Asian Journal of Chemistry,
Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015
Abstract
In this paper, we measured the dissolution enthalpies of biochanin A in DMSO using a RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric pressure and the results show that the dissolution process possessed an endothermic behaviour. A series of thermodynamics functions and half-life period were obtained from thermodynamic and kinetic calculations. This work not only provides a simple method to determine the half-life period of a drug but also offers a theoretical guide for the clinical application of biochanin A.
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References
A.B. Hendrich, J. Zugaj and K. Michalak, Cell. Mol. Biol. Lett., 7, 284 (2002).
C. Ying, J.T. Hsu and S.C. Shieh, Br. J. Nutr., 85, 615 (2001); doi:10.1079/BJN2000290.
M.C. Fung, Y.Y. Szeto, K.N. Leung, Y.L. Wong-Leung and N.K. Mak, Life Sci., 61, 105 (1997); doi:10.1016/S0024-3205(97)00365-2.
L. Rice, V.G. Samedi, T.A. Medrano, C.A. Sweeney, H.V. Baker, A. Stenstrom, J. Furman and K.T. Shiverick, Prostate, 52, 201 (2002); doi:10.1002/pros.10100.
C. Lin, Y.Y. Zeng, X.F. Zeng, L.Z. Zhao, T. Wang, H.X. Li and L.P. Li, Chinese Pharmacol. Bull., 23, 214 (2007).
C. Lin, Y.Y. Zeng, X.F. Zeng, L.Z. Zhao, X.Y. Huang and X.Y. Ye, J. Jinan Univ. (Med. Ed.), 28, 115 (2007).
R.L. Montgomery, R.A. Melaugh, C.C. Lau, G.H. Meier, H.H. Chan and F.D. Rossini, J. Chem. Thermodyn., 9, 915 (1977); doi:10.1016/0021-9614(77)90214-2.
L. Xue, F.Q. Zhao and X.L. Xing, Acta Phys. Chim. Sin., 25, 2413 (2009); doi:10.3866/PKU.WHXB20091129.
S.L. Gao, S.P. Chen, R.Z. Hu, H.Y. Li and Q.Z. Shi, Wuji Huaxue Xuebao, 2002, 18,362 (2002).