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Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

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Raman Spectra, Molecular Modeling and Biological Studies on Buffering Agent Metal Complexes

https://doi.org/10.14233/ajchem.2015.18839
Fawaz Saad
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makah, Saudi Arabia
Khlood S. Abou-Melha
Chemistry Department, Faculty of Science of Girls, King Khalid University, Saudi Arabia
Nashwa M. El-Metwaly
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makah, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

Corresponding Author(s) : Nashwa M. El-Metwaly

n_elmetwaly00@yahoo.com

Asian Journal of Chemistry, Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015

Abstract

Some transition metal complexes was prepared using a trizma buffering agent as a coordinating ligand. A slim organic compound used, produces a simple complexes serve in biological application. The complexes are investigated through elemental, thermal, spectral and molecular modeling. The general coordination binding mode of the ligand is the bidentate binding through a mononegative with Mn(II) and Cr(III) complexes, or neutral with Fe(III), Zn(II) and Cd(II) ions. The octahedral bonding distribution are proposed for all investigated metal complexes. The molecular modeling calculations reflect a shadow on comparative stability in between metal complexes. The biological investigation was concerned with the inhibition activity towards some bacteria as well as the degradation of DNA. Cadmium(II) complex displays the most insecticidal activity towards all used microorganisms. Also, all the complexes display a distinguish behavior towards DNA.

Keywords

Trizma complexes Raman DNA degradation Molecular modeling
Saad, F., S. Abou-Melha, K., & M. El-Metwaly, N. (2015). Raman Spectra, Molecular Modeling and Biological Studies on Buffering Agent Metal Complexes. Asian Journal of Chemistry, 27(7), 2678–2684. https://doi.org/10.14233/ajchem.2015.18839
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