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A New Cytotoxic Prenylated Chalcone from Desmodium renifolium
Corresponding Author(s) : Yan-Qing Ye
Asian Journal of Chemistry,
Vol. 27 No. 7 (2015): Vol 27 Issue 7, 2015
Abstract
A new prenylated chalcone, 2',5-dihydroxy-4,4'-dimethoxy-3-prenyl-chalcone (1), was isolated from whole Desmodium renifolium plants. Its structure was determined by spectroscopic methods including 1D and 2D NMR. Compound 1 was evaluated for its cytotoxicity using five tumor cell lines ((NB4, A549, SHSY5Y, PC3 and MCF7). It exhibited cytotoxicity against NB4 and MCF7 cell with IC50 values of 5.8 and 6.9 μM, respectively.
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- Editorial Committee of China Flora, Flora China, Vol. 41, p. 35 (1955).
- S.W. Zhao and Z.Y. Dao, Records for Dai medicine of Xishuangbanna., Vol. 2, pp. 263-265 (1981).
- H. Sasaki, Y. Kashiwada, H. Shibata and Y. Takaishi, Phytochemistry, 82, 136 (2012); doi:10.1016/j.phytochem.2012.06.007.
- H. Sasaki, H. Sato, Y. Kashiwada, K. Kawazoe, K. Murakami, H. Shibata, H.D. Sun, S.L. Li and Y. Takaishi, Planta Med., 78, 1851 (2012); doi:10.1055/s-0032-1320946.
- X. Ma, C. Zheng, C. Hu, K. Rahman and L. Qin, J. Ethnopharmacol., 138, 314 (2011); doi:10.1016/j.jep.2011.09.053.
- A. Yenesew, M. Induli, S. Derese, J.O. Midiwo, M. Heydenreich, M.G. Peter, H. Akala, J. Wangui, P. Liyala and N.C. Waters, Phytochemistry, 65, 3029 (2004); doi:10.1016/j.phytochem.2004.08.050.
- B.P. Bandgar, S.S. Jalde, L.K. Adsul, S.N. Shringare, S.V. Lonikar, R.N. Gacche, N.A. Dhole, S.H. Nile and A.L. Shirfule, Med. Chem. Res., 21, 4512 (2012); doi:10.1007/s00044-012-9979-z.
- P. Champelovier, M. Mininno, E. Duchamp, E. Nicolle, V. Curri, A. Boumendjel and J. Boutonnat, Anticancer Res., 31, 3213 (2011).
- M.M. Wu, L.Q. Wang, Y. Hua, Y.G. Chen, Y.Y. Wang, X.Y. Li, Y. Li, T. Li, X.Y. Yang and Z.-R. Tang, Planta Med., 77, 481 (2011); doi:10.1055/s-0030-1250492.
- J.H. Lee, N.I. Baek, S.H. Kim, H.W. Park, J.H. Yang, J.J. Lee, S.J. Kim, S. Jeong, C.-H. Oh, K.-H. Lee and D.K. Kim, Arch. Pharm. Res., 30, 408 (2007); doi:10.1007/BF02980212.
- X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.
References
Editorial Committee of China Flora, Flora China, Vol. 41, p. 35 (1955).
S.W. Zhao and Z.Y. Dao, Records for Dai medicine of Xishuangbanna., Vol. 2, pp. 263-265 (1981).
H. Sasaki, Y. Kashiwada, H. Shibata and Y. Takaishi, Phytochemistry, 82, 136 (2012); doi:10.1016/j.phytochem.2012.06.007.
H. Sasaki, H. Sato, Y. Kashiwada, K. Kawazoe, K. Murakami, H. Shibata, H.D. Sun, S.L. Li and Y. Takaishi, Planta Med., 78, 1851 (2012); doi:10.1055/s-0032-1320946.
X. Ma, C. Zheng, C. Hu, K. Rahman and L. Qin, J. Ethnopharmacol., 138, 314 (2011); doi:10.1016/j.jep.2011.09.053.
A. Yenesew, M. Induli, S. Derese, J.O. Midiwo, M. Heydenreich, M.G. Peter, H. Akala, J. Wangui, P. Liyala and N.C. Waters, Phytochemistry, 65, 3029 (2004); doi:10.1016/j.phytochem.2004.08.050.
B.P. Bandgar, S.S. Jalde, L.K. Adsul, S.N. Shringare, S.V. Lonikar, R.N. Gacche, N.A. Dhole, S.H. Nile and A.L. Shirfule, Med. Chem. Res., 21, 4512 (2012); doi:10.1007/s00044-012-9979-z.
P. Champelovier, M. Mininno, E. Duchamp, E. Nicolle, V. Curri, A. Boumendjel and J. Boutonnat, Anticancer Res., 31, 3213 (2011).
M.M. Wu, L.Q. Wang, Y. Hua, Y.G. Chen, Y.Y. Wang, X.Y. Li, Y. Li, T. Li, X.Y. Yang and Z.-R. Tang, Planta Med., 77, 481 (2011); doi:10.1055/s-0030-1250492.
J.H. Lee, N.I. Baek, S.H. Kim, H.W. Park, J.H. Yang, J.J. Lee, S.J. Kim, S. Jeong, C.-H. Oh, K.-H. Lee and D.K. Kim, Arch. Pharm. Res., 30, 408 (2007); doi:10.1007/BF02980212.
X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.