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Vol. 28 No. 1 (2016): Vol 28 Issue 1

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Synthesis, Characterization and Antimicrobial Evaluation of (E)-N'-[(1-(2-methoxy-6-pentadecylbenzyl)-1H-1,2,3-triazol-4-yl]methylene)benzohydrazide Derivatives

https://doi.org/10.14233/ajchem.2016.19310
N. Rambabu
Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad-500 072, India; Syngene International Ltd, Biocon Park, Plot No. 2 & 3, Bommasandra IV Phase, Banglore-560 099, India
P.K. Dubey
Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad-500 072, India
B. Ram
Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India
B. Balram
Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India

Corresponding Author(s) : N. Rambabu

rambabun2013@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 1 (2016): Vol 28 Issue 1

Abstract

Anacardic acid (pentadecyl salicylic acid) is a phenolic constituent present in cashew nut shell liquid (Anacardium occidentale L.) and exhibits antimicrobial properties. The present paper describes the synthesis, characterization and antimicrobial evaluation of hydrazone derivatives of anacardic acid (9a-l) linked with 1,2,3-triazole ring. All the newly synthesized compounds were determined by 1H NMR, mass and IR spectroscopy. Compounds 9d, 9e, 9h, 9i and 9j exhibited strong antifungal activity against the tested fungal strains viz., A. niger and C. albicans.

Keywords

Anacardic acid Antibacterial Antifungal Hydrazone 1,2,3-Triazole
Rambabu, N., Dubey, P., Ram, B., & Balram, B. (2015). Synthesis, Characterization and Antimicrobial Evaluation of (E)-N’-[(1-(2-methoxy-6-pentadecylbenzyl)-1H-1,2,3-triazol-4-yl]methylene)benzohydrazide Derivatives. Asian Journal of Chemistry, 28(1), 175–180. https://doi.org/10.14233/ajchem.2016.19310
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