Copyright (c) 2015 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
A New Isoflavanone from Desmodium oxyphyllum and Its Cytotoxicity
Corresponding Author(s) : Xue-Mei Gao
Asian Journal of Chemistry,
Vol. 27 No. 6 (2015): Vol 27 Issue 6
Abstract
A new isoflavanone, (3R) 4',7-methoxy-5-methoxycarbonyl-isoflavanone (1) was isolated from Desmodium oxyphyllum. This new compound was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed potential cytotoxicity against NB4 and PC3 cell with IC50 values of 5.6 and 7.2 μM.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- G.F. Li, T.Q. Chen, K.Y. Lang, T. Hong and Q. Lin, Higher Plants of China, Qingdao Publishing House, Qingdao, China, p. 152 (2008).
- Editorial Committee of Zhonghua Bencao National Traditional Chinese Herb Administration, Zhonghua Bencao (Chinese Herbal Medicine), Shanghai Science and Technology Publishing House, Shanghai, pp. 600-601 (1999).
- Editorial Committee of Jiangsu New Medical College, Dictionary of Chinese Medicinal Materials. Shanghai Science and Technology Press, Shanghai, p. 2512, 4106, 4294 (1977).
- D. Ghosh and A. Anandakumar, Indian J. Pharm., 15, 391 (1983).
- G.D. Monache, B. Botta, V. Vinciguerra, J. de Mello and A. de Andrade Chiappeta, Phytochemistry, 41, 537 (1996); doi:10.1016/0031-9422(95)00653-2.
- N. Gan, X. Yang, T.H. Li and P. He, Chin. J. Chin. Mater. Med., 33, 2077 (2008).
- G. Ning, L. Tianhua, Y. Xin and P. He, Chin. Tradit. Herbal Drugs, 40, 852 (2009).
- Editorial Committee of Fujian Institute of Chinese Medicine, Fujian Materia Medica, Fujian Science and Technology Press, Fuzhou, vol. II, p. 519, 520, vol. I, p. 205, 312, 326, 327, 328, 332 (1994).
- M. Mizuno, K. Baba, M. Iinuma and T. Tanaka, Phytochemistry, 31, 361 (1992); doi:10.1016/0031-9422(91)83080-5.
- Q.F. Hu, D.Y. Niu, B. Zhou, Y.Q. Ye, G. Du, C.Y. Meng and X.M. Gao, Bull. Korean Chem. Soc., 34, 3013 (2013); doi:10.5012/bkcs.2013.34.10.3013.
- G. Zappia, M.P. Menendez, C.S. de Andrade Lima and B. Botta, Nat. Prod. Res., 23, 665 (2009); doi:10.1080/14786410802362717.
- D. Slade, D. Ferreira and J.P.J. Marais, Phytochemistry, 66, 2177 (2005); doi:10.1016/j.phytochem.2005.02.002.
- X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.
References
G.F. Li, T.Q. Chen, K.Y. Lang, T. Hong and Q. Lin, Higher Plants of China, Qingdao Publishing House, Qingdao, China, p. 152 (2008).
Editorial Committee of Zhonghua Bencao National Traditional Chinese Herb Administration, Zhonghua Bencao (Chinese Herbal Medicine), Shanghai Science and Technology Publishing House, Shanghai, pp. 600-601 (1999).
Editorial Committee of Jiangsu New Medical College, Dictionary of Chinese Medicinal Materials. Shanghai Science and Technology Press, Shanghai, p. 2512, 4106, 4294 (1977).
D. Ghosh and A. Anandakumar, Indian J. Pharm., 15, 391 (1983).
G.D. Monache, B. Botta, V. Vinciguerra, J. de Mello and A. de Andrade Chiappeta, Phytochemistry, 41, 537 (1996); doi:10.1016/0031-9422(95)00653-2.
N. Gan, X. Yang, T.H. Li and P. He, Chin. J. Chin. Mater. Med., 33, 2077 (2008).
G. Ning, L. Tianhua, Y. Xin and P. He, Chin. Tradit. Herbal Drugs, 40, 852 (2009).
Editorial Committee of Fujian Institute of Chinese Medicine, Fujian Materia Medica, Fujian Science and Technology Press, Fuzhou, vol. II, p. 519, 520, vol. I, p. 205, 312, 326, 327, 328, 332 (1994).
M. Mizuno, K. Baba, M. Iinuma and T. Tanaka, Phytochemistry, 31, 361 (1992); doi:10.1016/0031-9422(91)83080-5.
Q.F. Hu, D.Y. Niu, B. Zhou, Y.Q. Ye, G. Du, C.Y. Meng and X.M. Gao, Bull. Korean Chem. Soc., 34, 3013 (2013); doi:10.5012/bkcs.2013.34.10.3013.
G. Zappia, M.P. Menendez, C.S. de Andrade Lima and B. Botta, Nat. Prod. Res., 23, 665 (2009); doi:10.1080/14786410802362717.
D. Slade, D. Ferreira and J.P.J. Marais, Phytochemistry, 66, 2177 (2005); doi:10.1016/j.phytochem.2005.02.002.
X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.