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Isolation of 11b-Hydroxycedrelone from Walsura yunnanensis and its Cytotoxic Activity
Corresponding Author(s) : Lihui Jiang
Asian Journal of Chemistry,
Vol. 27 No. 6 (2015): Vol 27 Issue 6
Abstract
11b-Hydroxycedrelone was isolated from the twigs and leaves of Walsura yunnanensis C. Y. Wu. Its structure was established on the basis of spectroscopic methods. 11b-Hydroxycedrelone featured a typical rearranged A-ring structure of this compound class. Cytotoxic evaluation showed that its exhibited moderate inhibitory activity against HL-60 cell line with the IC50 values of 8.9 μM.
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References
S.K. Chen, B.Y. Chen and H. Li, Flora of China (Zhongguo Zhiwu Zhi), Vol. 43(3), Science Press, Beijing, p. 62 (1997).
L.H. Jiang, Chem. Nat. Comp., 48, 1013 (2013); doi:10.1007/s10600-013-0452-0.
T.R. Govindachari, G.N. Krishna Kumari and G. Suresh, Phytochemistry, 39, 167 (1995); doi:10.1016/0031-9422(94)00851-J.
K. Balakrishna, R.B. Rao, A. Patra and S.U. Ali, Fitoterapia, 66, 548 (1995).
X.D. Luo, S.H. Wu, Y.B. Ma and D.G. Wu, J. Nat. Prod., 63, 947 (2000); doi:10.1021/np990607x.
X.D. Luo, D.G. Wu, X.H. Cai and E.J. Kennelly, Chem. Biodivers., 3, 224 (2006); doi:10.1002/cbdv.200690026.
H.D. Chen, S.P. Yang, Y. Wu, L. Dong and J.M. Yue, J. Nat. Prod., 72, 685 (2009); doi:10.1021/np800811b.
J.N. Xiang, L.H. Jiang, Ch.Y. Chen, Zh.Y. Fu, J.F. Duan, X.X. He and K.M. Wang, J. Carbohydr. Chem., 25, 595 (2006); doi:10.1080/07328300600966497.
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Q.M. Xu, Y.L. Liu, Y.L. Feng, L.H. Tang and Sh.L. Yang, Chem. Nat. Comp., 48, 597 (2012); doi:10.1007/s10600-012-0321-2.
H. Yun, C. Lijian, Z. Wenhong, D. Yuhong, W. Yongli, W. Qiang and Z. Ding, Chem. Nat. Comp., 43, 672 (2007); doi:10.1007/s10600-007-0225-8.
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