Issue

Vol. 27 No. 6 (2015): Vol 27 Issue 6

Copyright (c) 2015 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Isolation of New Xanthone from Hypericum chinense and Its Cytotoxicity

https://doi.org/10.14233/ajchem.2015.17780
Jie Lou
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Huan Wang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Gui-You Liu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Juan-Xia Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Limei Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Qiu-Fen Hu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China
Xue-Mei Gao
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Corresponding Author(s) : Xue-Mei Gao

gao_xuemei@hotmail.com

Asian Journal of Chemistry, Vol. 27 No. 6 (2015): Vol 27 Issue 6

Abstract

A new xanthone, hypexanthone A (1) was isolated from the leaves and stems of Hypericum chinense. Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 1 was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed cytotoxicity against NB4 and SHSY5Y cell with IC50 values of 5.2 and 6.3 μM, respectively.

Keywords

Xanthone Hypexanthone A Hypericum chinense
Lou, J., Wang, H., Liu, G.-Y., Yang, J.-X., Li, L., Hu, Q.-F., & Gao, X.-M. (2015). Isolation of New Xanthone from Hypericum chinense and Its Cytotoxicity. Asian Journal of Chemistry, 27(6), 2102–2104. https://doi.org/10.14233/ajchem.2015.17780
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. M.M. Pinto, M.E. Sousa and M.S. Nascimento, Curr. Med. Chem., 12, 2517 (2005); doi:10.2174/092986705774370691.
  2. K.S. Masters and S. Brase, Chem. Rev., 112, 3717 (2012); doi:10.1021/cr100446h.
  3. C.M. Cao, H. Zhang, R.J. Gallagher and B.N. Timmermann, Planta Med., 79, 697 (2013); doi:10.1055/s-0033-1348748.
  4. Y.P. Wu, W. Zhao, Z.Y. Xia, G.H. Kong, X.P. Lu, Q.F. Hu and X.M. Gao, Molecules, 18, 9663 (2013); doi:10.3390/molecules18089663.
  5. S. Klaiklay, Y. Sukpondma, V. Rukachaisirikul and S. Phongpaichit, Phytochemistry, 85, 161 (2013); doi:10.1016/j.phytochem.2012.08.020.
  6. H.R. Dharmaratne, Y. Sakagami, K.G. Piyasena and V. Thevanesam, Nat. Prod. Res., 27, 938 (2013); doi:10.1080/14786419.2012.678348.
  7. S. Udomchotphruet, P. Phuwapraisirisan, J. Sichaem and S. Tip-Pyang, Phytochemistry, 73, 148 (2012); doi:10.1016/j.phytochem.2010.04.028.
  8. C. Uvarani, K. Chandraprakash, M. Sankaran, A. Ata and P.S. Mohan, Nat. Prod. Res., 26, 1265 (2012); doi:10.1080/14786419.2011.561494.
  9. M. Ali, M. Arfan, M. Ahmad, K. Singh, I. Anis, H. Ahmad, M.I. Choudhary and M.R. Shah, Planta Med., 77, 2013 (2011); doi:10.1055/s-0031-1280114.
  10. H.Y. Yang, Y.H. Gao, D.Y. Niu, L.Y. Yang, X.M. Gao, G. Du and Q.F. Hu, Fitoterapia, 91, 189 (2013); doi:10.1016/j.fitote.2013.09.004.
  11. Q. Hu, X. Gao, D. Niu, X. Li, Y. Qin, Z. Yang, G. Zhao, Z. Yang and Z. Chen, Heterocycles, 87, 1127 (2013); doi:10.3987/COM-13-12713.
  12. N. Tanaka, Y. Kashiwada, S.Y. Kim, M. Sekiya, Y. Ikeshiro and Y. Takaishi, Phytochemistry, 70, 1456 (2009); doi:10.1016/j.phytochem.2009.08.015.
  13. Z.Y. Xiao and Q. Mu, Nat. Prod. Res. Dev., 19, 344 (2007).
  14. S. Abe, N. Tanaka and J. Kobayashi, J. Nat. Prod., 75, 484 (2012); doi:10.1021/np200741x.
  15. N. Tanaka, S. Abe, K. Hasegawa, M. Shiro and J. Kobayashi, Org. Lett., 13, 5488 (2011); doi:10.1021/ol2021548.
  16. W. Wang, Y.H. Zeng, K. Osman, K. Shinde, M. Rahman, S. Gibbons and Q. Mu, J. Nat. Prod., 73, 1815 (2010); doi:10.1021/np1004483.
  17. Y.P. Wu, W. Zhao, Z.Y. Xia, G.H. Kong, X.P. Lu, Q.F. Hu and X.M. Gao, Phytochem. Lett., 6, 629 (2013); doi:10.1016/j.phytol.2013.08.006.
  18. C. Morel, D. Seraphin, J.M. Oger, M. Litaudon, T. Sevenet, P. Richomme and J. Bruneton, J. Nat. Prod., 63, 1471 (2000); doi:10.1021/np000215m.
  19. X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0