Synthesis and Antibacterial Studies of 1-[3-(Trifluoromethoxy)phenylmethanone]piperidine-4-carboxylic Acid Derivatives

V.B. Reddy; V.K. Prasad; P. Venkataramana

doi:10.14233/ajchem.2016.19279

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Issue Published : October 5, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antibacterial Studies of 1-[3-(Trifluoromethoxy)phenylmethanone]piperidine-4-carboxylic Acid Derivatives

https://doi.org/10.14233/ajchem.2016.19279

V.B. Reddy

Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, India

V.K. Prasad

Denisco Chemicals Pvt. Ltd., Hyderabad-500 855, India

P. Venkataramana

Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, India

Corresponding Author(s) : P. Venkataramana

ramanapv2013@yahoo.com; ramanapv2013@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 1 (2016): Vol 28 Issue 1
Article Published : October 6, 2015

Abstract

Synthesis of novel piperidine-4-carboxamide derivatives as antibacterial agents has elevated impact on medicinal field. In the present work, ten new compounds were synthesized and screened toward their antibacterial studies. The structures of these compounds were characterized and analyzed by spectral studies such as IR, mass and ¹H NMR and compounds 6a and 6c-6h, were observed to possess potent antimicrobial activity.

Keywords

Derivatives of piperidine-4-carboxamide Synthesis Antibacterial screening

Reddy, V., Prasad, V., & Venkataramana, P. (2015). Synthesis and Antibacterial Studies of 1-[3-(Trifluoromethoxy)phenylmethanone]piperidine-4-carboxylic Acid Derivatives. Asian Journal of Chemistry, 28(1), 138–142. https://doi.org/10.14233/ajchem.2016.19279

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References

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References

M.G.P. Buffat, Tetrahedron, 60, 1701 (2004); doi:10.1016/j.tet.2003.11.043.

I. Ojima and D.M. Iula, in ed.: S.W. Pelletier, Chemical and Biological Perspectives, Elsevier Science Ltd, UK, edn 13, pp. 371-410 (1999).

P.M. Weintraub, J.S. Sabol, J.M. Kane and D.R. Borcherding, Tetrahedron, 59, 2953 (2003); doi:10.1016/S0040-4020(03)00295-3.

Z. Dang, Y. Yang, R. Ji and S. Zhang, Bioorg. Med. Chem. Lett., 17, 4523 (2007); doi:10.1016/j.bmcl.2007.05.093.

H.-N. Shin, S.H. Seo, H. Choo, G. Kuem, K.I. Choi and G. Nam, Bioorg. Med. Chem. Lett., 23, 1193 (2013); doi:10.1016/j.bmcl.2013.01.033.

C.L. Cavallaro, S. Briceno, J. Chen, M.E. Cvijic, P. Davies, J. Hynes Jr., R.-Q. Liu, S. Mandlekar, A.V. Rose, A.J. Tebben, K. Van Kirk, A. Watson, H. Wu, G. Yang and P.H. Carter, J. Med. Chem., 55, 9643 (2012); doi:10.1021/jm300896d.

H. Khalid, Aziz-ur-Rehman, K.M. Khan, Int. J. Pharm. Pharmaceut. Sci., 4, 443 (2012).

S.P. Kalpesh and P.V. Sandip, Der Chemica Sinica, 3, 430 (2012).

M.K. Prashanth, H.D. Revanasiddappa, K.M. Lokanatha Rai and B. Veeresh, Bioorg. Med. Chem. Lett., 22, 7065 (2012); doi:10.1016/j.bmcl.2012.09.089.

Y.-Y. Zheng, L. Guo, X.-C. Zhen and J.-Q. Li, Eur. J. Med. Chem., 54, 123 (2012); doi:10.1016/j.ejmech.2012.04.030.

B.J. Mavunkel, J.J. Perumattam, X. Tan, G.R. Luedtke, Q. Lu, D. Lim, D. Kizer, S. Dugar, S. Chakravarty, Y. Xu, J. Jung, A. Liclican, D.E. Levy and J. Tabora, Bioorg. Med. Chem. Lett., 20, 1059 (2010); doi:10.1016/j.bmcl.2009.12.031.

X. Chen, P. Zhan, X. Liu, Z. Cheng, C. Meng, S. Shao, C. Pannecouque, E. De Clercq and X. Liu, Bioorg. Med. Chem., 20, 3856 (2012); doi:10.1016/j.bmc.2012.04.030.

X. Chen, P. Zhan, C. Pannecouque, J. Balzarini, E. De Clercq and X.Liu, Eur. J. Med. Chem., 51, 60 (2012); doi:10.1016/j.ejmech.2012.02.019.

S. Watanuki, K. Matsuura, Y. Tomura, M. Okada, T. Okazaki, M. Ohta and S. Tsukamoto, Bioorg. Med. Chem., 19, 5628 (2011); doi:10.1016/j.bmc.2011.07.030.

X.-H. Liu, J. Li, J.B. Shi, B.-A. Song and X.-B. Qi, Eur. J. Med. Chem., 51, 294 (2012); doi:10.1016/j.ejmech.2012.02.040.

V.B.P. Reddy, P. Prasad and P. Venkataramana, J. Applicable Chem., 2, 1501 (2013).

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Synthesis and Antibacterial Studies of 1-[3-(Trifluoromethoxy)phenylmethanone]piperidine-4-carboxylic Acid Derivatives

Corresponding Author(s) : P. Venkataramana

Abstract

Keywords

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