Simultaneous Determination of Four Neuritogenic Compounds in Gentiana rigescens from Different Regions by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Yu Pan; Tao Shen; Jun Pan; Dan Xiao; Zhi-Min Li; Wan-Yi Li; Yuan-Zhong Wang

doi:10.14233/ajchem.2015.17433

Issue

Vol. 27 No. 4 (2015): Vol 27 Issue 4

Issue Published : February 4, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Simultaneous Determination of Four Neuritogenic Compounds in Gentiana rigescens from Different Regions by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

https://doi.org/10.14233/ajchem.2015.17433

Yu Pan

Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P.R. China; College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, P.R. China

Tao Shen

College of Resources and Environment, Yuxi Normal University, Yuxi 653100, P.R. China

Jun Pan

Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P.R. China

Dan Xiao

Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P.R. China

Zhi-Min Li

Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P.R. China

Wan-Yi Li

Yuan-Zhong Wang

Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650200, P.R. China

Corresponding Author(s) : Wan-Yi Li

wyli2012@126.com; boletus@126.com

Asian Journal of Chemistry, Vol. 27 No. 4 (2015): Vol 27 Issue 4
Article Published : February 3, 2015

Abstract

The roots and rhizomes of Gentiana rigescens are the original materials of Chinese traditional medicine "LongDan" which is used for treatment of hepatitis and cholecystitis for over a thousand years. In this study, the concentrations of four gentisides (gentiside A, B, J and K) were determined by UPLC-MS/MS in Gentiana rigescens from 2 different regions (Yunxian and Yongde) of southwest Yunnan in China. The maximum concentration of gentiside A, B, J and K were found in S5, S12, S5 and S3, respectively. Hierarchical clustering analysis showed the maximum total concentration of gentisides was in group IV, which indicated S5 could be regarded as optimizing original materials of G. rigescens. The cultivated samples collected from Yunxian showed the higher contents of gentisides. These results would provide information for sustainable utilization of G. rigescens.

Keywords

Gentiana rigescens Gentisides Different regions UPLC-MS/MS

Pan, Y., Shen, T., Pan, J., Xiao, D., Li, Z.-M., Li, W.-Y., & Wang, Y.-Z. (2015). Simultaneous Determination of Four Neuritogenic Compounds in Gentiana rigescens from Different Regions by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry. Asian Journal of Chemistry, 27(4), 1247–1250. https://doi.org/10.14233/ajchem.2015.17433

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References

State Pharmacopoeia Commission, Chinese Pharmacopoeia, Chemistry and Industry Press, Beijing, Vol. 1, pp. 89-90 (2010).
Z.Y. Wu, Flora of China, Beijing, Vol. 62, pp. 100-101 (1988).
M. Xu, D. Wang, Y.J. Zhang and C.R. Yang, Acta Botaninca Yunnanica, 28, 669 (2006).
R.W. Jiang, K.L. Wong, Y.M. Chan, H.X. Xu, P.P.H. But and P.C. Shaw, Phytochemistry, 66, 2674 (2005); doi:10.1016/j.phytochem.2005.09.028.
M. Xu, C.R. Yang and Y.J. Zhang, Chin. Chem. Lett., 20, 1215 (2009); doi:10.1016/j.cclet.2009.05.006.
M. Xu, D. Wang, Y.J. Zhang and C.R. Yang, J. Nat. Prod., 70, 880 (2007); doi:10.1021/np070012z.
N.J. Sun and C.F. Xia, Chin. J. Chin. Mater. Med., 9, 33 (1985).
Z.M. Li, L. Zhao, Y.T. Bai, J.Y. Zhang, H. Jin and G.X. Rao, J. Yunnan Univ. Tradit. Chin. Med., 31, 10 (2008).
L. Zhao, Z.M. Li, J. Yang, J.Y. Zhang, H. Jin and G.X. Rao, J. Yunnan Univ. Tradit. Chin. Med., 31, 23 (2008).
X.Y. Cao and Z.Z. Wang, Phytochem. Anal., 21, 348 (2010); doi:10.1002/pca.1206.
L. Gao, J. Li and J. Qi, Bioorg. Med. Chem., 18, 2131 (2010); doi:10.1016/j.bmc.2010.02.004.
L. Gao, L. Xiang, Y. Luo, G. Wang, J. Li and J. Qi, Bioorg. Med. Chem., 18, 6995 (2010); doi:10.1016/j.bmc.2010.08.020.
F.T. Peters, Clin. Biochem., 44, 54 (2011); doi:10.1016/j.clinbiochem.2010.08.008.
J. Zhang, J. Lu, Q. Zhang, L. Dai, Y. Liu, P. Tu and Y. Qiao, J. Chromatogr. Sci., 52, 103 (2014); doi:10.1093/chromsci/bms253.
C.C. Leandro, P. Hancock, R.J. Fussell and B.J. Keely, J. Chromatogr. A, 1103, 94 (2006); doi:10.1016/j.chroma.2005.10.077.
J. Zhou, J. Zhao, H. Yuan, Y. Meng, Y. Li, L. Wu and X. Xue, Chromatographia, 66, 185 (2007); doi:10.1365/s10337-007-0305-8.
T. Wu, C. Wang, X. Wang, H. Xiao, Q. Ma and Q. Zhang, Chromatographia, 68, 803 (2008); doi:10.1365/s10337-008-0788-y.
Y. Pan, T. Shen, J. Pan, D. Xiao, Z. Li, W. Li and Y. Wang, Anal. Methods, 6, 1782 (2014); doi:10.1039/C3AY41923A.

References

State Pharmacopoeia Commission, Chinese Pharmacopoeia, Chemistry and Industry Press, Beijing, Vol. 1, pp. 89-90 (2010).

Z.Y. Wu, Flora of China, Beijing, Vol. 62, pp. 100-101 (1988).

M. Xu, D. Wang, Y.J. Zhang and C.R. Yang, Acta Botaninca Yunnanica, 28, 669 (2006).

R.W. Jiang, K.L. Wong, Y.M. Chan, H.X. Xu, P.P.H. But and P.C. Shaw, Phytochemistry, 66, 2674 (2005); doi:10.1016/j.phytochem.2005.09.028.

M. Xu, C.R. Yang and Y.J. Zhang, Chin. Chem. Lett., 20, 1215 (2009); doi:10.1016/j.cclet.2009.05.006.

M. Xu, D. Wang, Y.J. Zhang and C.R. Yang, J. Nat. Prod., 70, 880 (2007); doi:10.1021/np070012z.

N.J. Sun and C.F. Xia, Chin. J. Chin. Mater. Med., 9, 33 (1985).

Z.M. Li, L. Zhao, Y.T. Bai, J.Y. Zhang, H. Jin and G.X. Rao, J. Yunnan Univ. Tradit. Chin. Med., 31, 10 (2008).

L. Zhao, Z.M. Li, J. Yang, J.Y. Zhang, H. Jin and G.X. Rao, J. Yunnan Univ. Tradit. Chin. Med., 31, 23 (2008).

X.Y. Cao and Z.Z. Wang, Phytochem. Anal., 21, 348 (2010); doi:10.1002/pca.1206.

L. Gao, J. Li and J. Qi, Bioorg. Med. Chem., 18, 2131 (2010); doi:10.1016/j.bmc.2010.02.004.

L. Gao, L. Xiang, Y. Luo, G. Wang, J. Li and J. Qi, Bioorg. Med. Chem., 18, 6995 (2010); doi:10.1016/j.bmc.2010.08.020.

F.T. Peters, Clin. Biochem., 44, 54 (2011); doi:10.1016/j.clinbiochem.2010.08.008.

J. Zhang, J. Lu, Q. Zhang, L. Dai, Y. Liu, P. Tu and Y. Qiao, J. Chromatogr. Sci., 52, 103 (2014); doi:10.1093/chromsci/bms253.

C.C. Leandro, P. Hancock, R.J. Fussell and B.J. Keely, J. Chromatogr. A, 1103, 94 (2006); doi:10.1016/j.chroma.2005.10.077.

J. Zhou, J. Zhao, H. Yuan, Y. Meng, Y. Li, L. Wu and X. Xue, Chromatographia, 66, 185 (2007); doi:10.1365/s10337-007-0305-8.

T. Wu, C. Wang, X. Wang, H. Xiao, Q. Ma and Q. Zhang, Chromatographia, 68, 803 (2008); doi:10.1365/s10337-008-0788-y.

Y. Pan, T. Shen, J. Pan, D. Xiao, Z. Li, W. Li and Y. Wang, Anal. Methods, 6, 1782 (2014); doi:10.1039/C3AY41923A.

Issue

Vol. 27 No. 4 (2015): Vol 27 Issue 4

Simultaneous Determination of Four Neuritogenic Compounds in Gentiana rigescens from Different Regions by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Corresponding Author(s) : Wan-Yi Li

Abstract

Keywords

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