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Vol. 31 No. 1 (2019): Vol 31 Issue 1

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Development of 5-(Aryl)-3-phenyl-1H-pyrazole Derivatives as Potent Antimicrobial Compounds

https://doi.org/10.14233/ajchem.2019.21455
B. Nagendra Chowdary
Post Graduate Department of Chemistry, Maharani’s Science College for Women, Mysore-570 005, India
M. Umashankara
Department of Studies in Chemistry, Karnataka State Open University, Mukthagangothri, Mysore-570006, India
B. Dinesh
Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India
K. Girish
Post Graduate Department of Microbiology, Maharani’s Science College for Women, Mysore-570005, India
A. Ramesha Baba
Post Graduate Department of Chemistry, Maharani’s Science College for Women, Mysore-570 005, India

Corresponding Author(s) : K. Girish

girishk77@yahoo.com

Asian Journal of Chemistry, Vol. 31 No. 1 (2019): Vol 31 Issue 1

Abstract

A series of 16 chalcone compounds were synthesized by Claisen-Schmidt condensation of various aldehydes with acetophenone using KOH as a base in ethanol. The reaction affords the desired products in good yields. Then all the 16 compounds were converted into pyrazoles by treating with hydrazine hydrate in ethanol under reflux condition. Both chalcones and pyrazoles were screened for their in vitro antibacterial (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa) and antifungal (Aspergillus flavus, Chrysosporium keratinophilum and Candida albicans) activity. Biological activities of these compounds were compared with those of commercially available antibiotic ampicillin and antifungal agent miconazole. Pyrazoles were found to be most active and effective than corresponding chalcones for antimicrobial activity. Out of the 7 pyrazole compounds tested for antibacterial and antifungal activity, 5 compounds, 4h, 4j, 4l, 4m and 4n are turned out to be potent antimicrobial agents. Therefore these derivatives could serve as a highly promising molecules for further development.

Keywords

Antibacterial Antifungal Heterocyclic and Substituted pyrazoles Chalcone
Chowdary, B. N., Umashankara, M., Dinesh, B., Girish, K., & Baba, A. R. (2018). Development of 5-(Aryl)-3-phenyl-1H-pyrazole Derivatives as Potent Antimicrobial Compounds. Asian Journal of Chemistry, 31(1), 45–50. https://doi.org/10.14233/ajchem.2019.21455
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