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Vol. 27 No. 4 (2015): Vol 27 Issue 4

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Simultaneous Quantitative Determination of Nonoxynol-9, Acrylamide, Sorbic Acid and Sodium Cyclamate in Toothpaste by HPLC-MS/MS

https://doi.org/10.14233/ajchem.2015.17151
Jun-Xian Zhang
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China; Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, P.R. China
Ming-Ming Miao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Xue-Mei Niu
Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, P.R. China
Su-Juan Wang
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Yi Han
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Ke-Qin Zhang
Laboratory for Conservation and Utilization of Bio-Resources and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, P.R. China
Cheng-Ming Zhang
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Corresponding Author(s) : Cheng-Ming Zhang

969657214@163.com

Asian Journal of Chemistry, Vol. 27 No. 4 (2015): Vol 27 Issue 4

Abstract

A new method for simultaneous determination and quantitation of nonoxynol-9, acrylamide, sorbic acid and sodium cyclamate in toothpaste has been developed by using high performance liquid chromatography-Tandem mass spectrometry (HPLC-MS/MS). The method is simple, sensitive and rapid. Recoveries were mostly higher than 90 %, method detection limits (MDLs) ranged from 1.69-2.77 ng mL-1 and method quantitation limits (MQLs) were included between 5.63-9.22 ng mL-1. Matrix effect was evaluated and quantitation was performed by referring to a matrix matched calibration curve to improve accuracy. This method was also applied to commercial toothpaste samples with good results.

Keywords

Nonoxynol-9 Acrylamide Sorbic acid Sodium cyclamate Toothpaste HPLC-MS/MS
Zhang, J.-X., Miao, M.-M., Niu, X.-M., Wang, S.-J., Han, Y., Zhang, K.-Q., & Zhang, C.-M. (2015). Simultaneous Quantitative Determination of Nonoxynol-9, Acrylamide, Sorbic Acid and Sodium Cyclamate in Toothpaste by HPLC-MS/MS. Asian Journal of Chemistry, 27(4), 1194–1198. https://doi.org/10.14233/ajchem.2015.17151
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