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Vol. 27 No. 4 (2015): Vol 27 Issue 4

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Fluorescence Spectrometry of Interaction of Acyclovir and Bovine Serum Albumin in Presence of Carbon Nanotubes

https://doi.org/10.14233/ajchem.2015.17603
Xiaoxia Wang
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Zhengde Wang
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Jinyan Liu
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Bin Hou
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Yunying Liu
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Hui Yan
School of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, P.R. China
Gaowa Aodeng
School of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, P.R. China

Corresponding Author(s) : Xiaoxia Wang

wxx572369@163.com

Asian Journal of Chemistry, Vol. 27 No. 4 (2015): Vol 27 Issue 4

Abstract

The interaction between acyclovir and bovine serum albumin in presence of carbon nanotubes was investigated by fluorescence spectrometry. Testing the fluorescence value of three material mixture by fluorescence spectrophotometer, scanning the synchronous fluorescence spectrum of acyclovir and bovine serum albumin and analyzing the quenching effect. The experimental results showed that fluorescence quenching of acyclovir for bovine serum albumin is mainly static quenching, acyclovir has a main fluorescence quenching effect on the tryptophan of bovine serum albumin and has no impact on the basic conformation of bovine serum albumin. The addition of carbon nanotubes in the binary mixture, the fluorescence quenching effect was more apparent and would become more obvious with the increasing amount of carbon nanotubes.

Keywords

Acyclovir Bovine serum albumin Carbon nanotubes Synchronous fluorescence Fluorescence quenching
Wang, X., Wang, Z., Liu, J., Hou, B., Liu, Y., Yan, H., & Aodeng, G. (2015). Fluorescence Spectrometry of Interaction of Acyclovir and Bovine Serum Albumin in Presence of Carbon Nanotubes. Asian Journal of Chemistry, 27(4), 1283–1286. https://doi.org/10.14233/ajchem.2015.17603
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