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Vol. 27 No. 4 (2015): Vol 27 Issue 4

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Electrocatalytic Reduction and Voltammetric Determination of Metronidazole at Inlaying Ultra-Thin Carbon Paste Electrode

https://doi.org/10.14233/ajchem.2015.18772
Haihong Zhan
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P.R. China; Department of Biochemistry, Pingdingshan Educational College, Pingdingshan 467000, P.R. China
Yuechun Qiao
Henan Mechanical and Electrical Engineering College, Xinxiang 453002, P.R. China
Quanmin Li
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P.R. China

Corresponding Author(s) : Quanmin Li

mercury6068@126.com

Asian Journal of Chemistry, Vol. 27 No. 4 (2015): Vol 27 Issue 4

Abstract

In this paper, nichrome was adopted as a substrate, to fabricate an inlaying ultra-thin carbon paste electrode (IUTCPE). Cyclic voltammetry and linear scan voltammetry were used to investigate the electrochemical responses of metronidazole. The results revealed that, in 0.1 mol L-1 Britton-Robinson buffer (pH 3), the inlaying ultra-thin carbon paste electrode showed a good electrocatalytic reduction towards metronidazole. Under optimized conditions, the well-defined reduction peak currents increased linearly with increasing the contents in the range of 7 × 10-7-1.17 × 10-3 mol/L. The detection limit (S/N = 3) was 2.8 × 10-7 mol/L. Inlaying ultra-thin carbon paste electrode has the advantages of simple procedure, good stability and low cost. The proposed method was successfully applied to metronidazole determination in tablets. The recovery was from 96.0 to 104.7 %.

Keywords

Inlaying ultra-thin carbon paste electrode Metronidazole Voltammetry Tablets analysis
Zhan, H., Qiao, Y., & Li, Q. (2015). Electrocatalytic Reduction and Voltammetric Determination of Metronidazole at Inlaying Ultra-Thin Carbon Paste Electrode. Asian Journal of Chemistry, 27(4), 1532–1536. https://doi.org/10.14233/ajchem.2015.18772
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