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(+) Corydine from the Stems of Tinospora cordifolia
Corresponding Author(s) : Prabir K. Chaudhuri
Asian Journal of Chemistry,
Vol. 27 No. 4 (2015): Vol 27 Issue 4
Abstract
The present work constitutes the systematic chemical screening of matured stems of Tinospora cordifolia as matured stems are preferred in commercial formulations for its efficacy. Earlier works on T. cordifolia collected from wild sources showed a lot of chemical variations with altogether different compounds which pose difficulties in its quality management as marker compounds. The stems of T. cordifolia were collected at matured stage from our gene bank and extracted with alcohol after its defatification with hexane. The isolated alkaloidal part on repeated Si-gel, flash and reversed phase C18 column chromatography afforded four isoquinoline alkaloids palmatine, jatrorrhizine, magnoflorine and (+) corydine. The non-alkaloidal part gave columbin, a furano diterpenoid beside b-sitosterol. (+) Corydine, a rare alkaloid was reported first time from T. cordifolia and from the genus Tinospora. The structures of compounds were identified by 2D NMR and MS analyses.
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References
Y.R. Chadha, The Wealth of India, Publication and Information Directorate, CSIR, New Delhi, vol. 10, p. 251 (1976).
C.K. Atal, M.L. Sharma, A. Kaul and A. Khajuria, J. Ethnopharmacol., 18, 133 (1986); doi:10.1016/0378-8741(86)90025-5.
P. Stanely, M. Prince and V.P. Menon, J. Ethnopharmacol., 70, 9 (2000); doi:10.1016/S0378-8741(99)00136-1.
D.N.K. Sarma, R.L. Khosa, J.P.N. Chansauria and M. Sahai, Phytother. Res., 9, 589 (1995); doi:10.1002/ptr.2650090811.
D.N.K. Sarma, R.L. Khosa, J.P.N. Chansauria and M. Sahai, Phytother. Res., 10, 181 (1996); doi:10.1002/(SICI)1099-1573(199603)10:2<181::AID-PTR804>3.0.CO;2-6.
M.B. Patel and S. Mishra, Phytomedicine, 18, 1045 (2011); doi:10.1016/j.phymed.2011.05.006.
V. Sharma and R. Gupta, Toxicol. Int, 18, 94 (2011); doi:10.4103/0971-6580.84259.
Y. Konda, Y. Imai, H. Hojo, T. Endo and S. Nozoe, J. Pharmacobiodyn., 13, 426 (1990); doi:10.1248/bpb1978.13.426.
X. Wang, H. Dong, B. Yang, D. Liu, W. Duan and L.J. Huang, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 879, 3767 (2011); doi:10.1016/j.jchromb.2011.10.013.
A. Shafiee and A.H. Jafarabadi, Planta Med., 64, 489 (1998); doi:10.1055/s-2006-957498.
T.S. Panchabhai, U.P. Kulkarni and N.N. Rege, Phytother. Res., 22, 425 (2008); doi:10.1002/ptr.2347.