Determination of 16 Phthalic Acid Esters in Medical Infusion Plastic Bottles by GC-MS

Hao Zhong; De-Zhou Ge; Zu-Lei Deng; Tao Ma; Hao Liu

doi:10.14233/ajchem.2015.17986

Issue

Vol. 27 No. 4 (2015): Vol 27 Issue 4

Issue Published : February 4, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Determination of 16 Phthalic Acid Esters in Medical Infusion Plastic Bottles by GC-MS

https://doi.org/10.14233/ajchem.2015.17986

Hao Zhong

Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, Anhui Province, P.R. China

De-Zhou Ge

Bengbu Institute for Food and Drug Control, Bengbu 233000, Anhui Province, P.R. China

Zu-Lei Deng

Bengbu Institute for Food and Drug Control, Bengbu 233000, Anhui Province, P.R. China

Tao Ma

Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, Anhui Province, P.R. China

Hao Liu

Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, Anhui Province, P.R. China

Corresponding Author(s) : De-Zhou Ge

Asian Journal of Chemistry, Vol. 27 No. 4 (2015): Vol 27 Issue 4
Article Published : February 4, 2015

Abstract

To establish a gas chromatograph mass spectrometer method for the determination of 16 phthalic acid esters (PAEs) in medical infusion plastic bottles. Sample pretreatment procedures involved of dichloromethane as extraction solvent and ultrasonic extraction method. There was a good linearity range of related 16 phthalic acid esters was observed. The correlation coefficient was ranged at 0.9907-0.9998. Low detection limits of 0.02-0.09 μg g^-1. The mean recoveries were in the range from 82.3 to 101.6 % at 8 and 1 μg g^-1 spiked levels and the relative standard deviations were in the range of 1.12 and 4.86 % (n = 6). Meanwhile, phthalic acid esters were determined in 40 medical infusion plastic bottles from four pharmaceutical companies in Bengbu city of Anhui province of China. The survey of 40 samples showed dimethyl phthalate, diisobuthyl phthalate and dicyclohexyl phthalate had 100 % (40:40), 87.5 % (35:40) and 45 % (18:40) detection rate. The dimethyl phthalate, diisobuthyl phthalate and dicyclohexyl phthalate were detected at the range of 0.06-0.6 μg g^-1, which indicated that more attention should be paid to the phthalic acid esters in medical infusion plastic bottles.

Keywords

Medical infusion plastic bottles Phthalate acid ester GC-MS

Zhong, H., Ge, D.-Z., Deng, Z.-L., Ma, T., & Liu, H. (2015). Determination of 16 Phthalic Acid Esters in Medical Infusion Plastic Bottles by GC-MS. Asian Journal of Chemistry, 27(4), 1375–1380. https://doi.org/10.14233/ajchem.2015.17986

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M.V. Russo, I. Notardonato, G. Cinelli and P. Avino, Anal. Bioanal. Chem., 402, 1373 (2012); doi:10.1007/s00216-011-5551-9.

B.Y. Chung, M. Kyung, S.K. Lim, S.M. Choi, D.S. Lim, S.J. Kwack, H.S. Kim and B.M. Lee. Toxicol. Environ. Health A, 76, 624 (2013); doi:10.1080/15287394.2013.801767.

X. Gao, B. Yang, Z. Tang, X. Luo, F. Wang, H. Xu and X. Cai, J. Chromatogr. Sci., 52, 383 (2014); doi:10.1093/chromsci/bmt046.

R. Sendon, A. Sanches-Silva, J. Bustos, P. Martin, N. Martinez and M.E. Cirugeda, J. Sep. Sci., 35, 1319 (2012); doi:10.1002/jssc.201100871.

Z. Guo, S. Wang, D. Wei, M. Wang, H. Zhang, P. Gai and J. Duan, Meat Sci., 84, 484 (2010); doi:10.1016/j.meatsci.2009.10.002.

I.V. Strac, M. Pusic, G. Gajski and V. Garaj-Vrhovac, J. Appl. Toxicol., 33, 214 (2013); doi:10.1002/jat.1741.

A.M. Saillenfait, F. Gallissot, J.P. Sabate and A. Remy, Reprod. Toxicol., 37, 49 (2013); doi:10.1016/j.reprotox.2013.01.004.

P. Wu, D. Yang, L. Zhang, X. Shen, X. Pan, L. Wang, J. Zhang, Y. Tan, L. Feng and Y. Ying, J. Sep. Sci., 35, 2932 (2012); doi:10.1002/jssc.201200462.

Y. Liu, S. Wang and L. Wang, J. Agric. Food Chem., 61, 1160 (2013); doi:10.1021/jf3053884.

N.R. Song, J.W. On, J. Lee, J.D. Park, H.J. Kwon, H.J. Yoon and H. Pyo, Environ. Int., 54, 65 (2013); doi:10.1016/j.envint.2013.01.007.

Z. Guo, D. Wei, M. Wang and S. Wang, J. Chromatogr. Sci., 48, 760 (2010); doi:10.1093/chromsci/48.9.760.

H. Yan, X. Cheng and G. Yang, J. Agric. Food Chem., 60, 5524 (2012); doi:10.1021/jf300660m.

M. Llompart, M. Celeiro, J. Pablo Lamas, L. Sanchez-Prado, M. Lores and C. Garcia-Jares, J. Chromatogr. A, 1293, 10 (2013); doi:10.1016/j.chroma.2013.03.067.

H. Li, F. Tian, X. Ren and X. Wang, Chinese J. Chromatogr., 29, 563 (2011); doi:10.3724/SP.J.1123.2011.00563.

A.V. Herrera-Herrera, J. Hernandez-Borges, M.M. Afonso, J.A. Palenzuela and M.A. Rodriguez-Delgado, Talanta, 116, 695 (2013); doi:10.1016/j.talanta.2013.07.060.

Q. Xu, X. Yin, M. Wang, H. Wang, N. Zhang, Y. Shen, S. Xu, L. Zhang and Z. Gu, J. Agric. Food Chem., 58, 11311 (2010); doi:10.1021/jf102821h.

M. Moazzen, R. Ahmadkhaniha, M.E. Gorji, M. Yunesian and N. Rastkari, Talanta, 115, 957 (2013); doi:10.1016/j.talanta.2013.07.005.

G. Huang, H.F. Li, B.T. Zhang, Y. Ma and J.M. Lin, Talanta, 100, 64 (2012); doi:10.1016/j.talanta.2012.08.009.

H. Sun, Y. Yang, H. Li, J. Zhang and N. Sun, J. Agric. Food Chem., 60, 5532 (2012); doi:10.1021/jf3009603.

S. Gartner, M. Balski, M. Koch and I. Nehls, J. Agric. Food Chem., 57, 10675 (2009); doi:10.1021/jf902683m.

Issue

Vol. 27 No. 4 (2015): Vol 27 Issue 4

Determination of 16 Phthalic Acid Esters in Medical Infusion Plastic Bottles by GC-MS

Corresponding Author(s) : De-Zhou Ge

Abstract

Keywords

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