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An Improved New Path to Synthesize Gemfibrozil
Corresponding Author(s) : N.D. Jayanna
Asian Journal of Chemistry,
Vol. 27 No. 3 (2015): Vol 27 Issue 3
Abstract
A new route has been developed for synthesis of gemfibrozil in good yield with high purity. The obtained gemfibrozil was characterized by using IR, 1H NMR, 13C NMR and mass spectral studies. According to Biopharmaceutical Classification System, gemfibrozil is classified under class-II drugs (low solubility-high permeability) and an antihyperlipidimic. So it's admirable to synthesize the intention molecule in easy and economical way.
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- P. Creger and W. Neuklis, US Patent 3759986, Chem. Abstr., 72, 43167 (1972).
- A.G. Olsson, S. Rossner, G. Walldius and L.A. Carlson, Proc. R. Soc. Med., 69 (Suppl. 2), 28 (1976); doi:10.1177/00359157760690S207.
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- Organic Synthesis Coll., 1, 435 (1941).
- Organic Synthesis Coll., 50, 58 (1970).
- Chem. Abstr., 108, 204330 (1988).
- Chem. Abstr., 82, 97837 (1975).
- Chem. Abstr., 107, 39419 (1987).
- Chem. Abstr., 106, 66899 (1987).
- Chem. Abstr., 109, 92281 (1988).
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References
P. Creger and W. Neuklis, US Patent 3759986, Chem. Abstr., 72, 43167 (1972).
A.G. Olsson, S. Rossner, G. Walldius and L.A. Carlson, Proc. R. Soc. Med., 69 (Suppl. 2), 28 (1976); doi:10.1177/00359157760690S207.
E.A. Nikkila, R. Ylikahri and J.K. Huttunen, Proc. R. Soc. Med., 69 (Suppl. 2), 58 (1976); doi:10.1177/00359157760690S215.
Y.A. Kesaniemi and S.M. Grundy, JAMA, 251, 2241 (1984); doi:10.1001/jama.1984.03340410049031.
V. Manninen, M.O. Elo, M.H. Frick, K. Happa, O.P. Heinonen, P. Heinsalmi, P. Helo, J.K. Huttunen, P. Kaitaniemi and P. Koskinen, JAMA, 260, 641 (1988); doi:10.1001/jama.1988.03410050061031.
J. Lewis, Multicenter Pract. Cardiol., 9, 99 (1983).
P.L. Creger, 2,2-Dimethyl-{11-aryloxy-alkanoic acids and salts and esters thereof), US Patent 3,674,836 (1972).
Organic Synthesis Coll., 1, 435 (1941).
Organic Synthesis Coll., 50, 58 (1970).
Chem. Abstr., 108, 204330 (1988).
Chem. Abstr., 82, 97837 (1975).
Chem. Abstr., 107, 39419 (1987).
Chem. Abstr., 106, 66899 (1987).
Chem. Abstr., 109, 92281 (1988).
Chem. Abstr., 103, 123144 (1985).
R.S. Jose, B.B. Jose Ignacio and F.G. Eugenio, Chem. Abstr., 106, 66916 (1987).