Synthesis and Anticancer Evaluation of Novel 10-Methoxycamptothecin Derivatives

Meixuan Zhu; Lijia Jing; Shaoming Wang; Sheng Zhang; Yang Wang

doi:10.14233/ajchem.2015.17599

Issue

Vol. 27 No. 3 (2015): Vol 27 Issue 3

Issue Published : January 19, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Anticancer Evaluation of Novel 10-Methoxycamptothecin Derivatives

https://doi.org/10.14233/ajchem.2015.17599

Meixuan Zhu

Alkali Soil Nature Environmental Science Center, Northeast Forestry University, Harbin 150040, P.R. China

Lijia Jing

Alkali Soil Nature Environmental Science Center, Northeast Forestry University, Harbin 150040, P.R. China

Shaoming Wang

Alkali Soil Nature Environmental Science Center, Northeast Forestry University, Harbin 150040, P.R. China

Sheng Zhang

Alkali Soil Nature Environmental Science Center, Northeast Forestry University, Harbin 150040, P.R. China

Yang Wang

Alkali Soil Nature Environmental Science Center, Northeast Forestry University, Harbin 150040, P.R. China

Corresponding Author(s) : Yang Wang

ywang@nefu.edu.cn

Asian Journal of Chemistry, Vol. 27 No. 3 (2015): Vol 27 Issue 3
Article Published : January 18, 2015

Abstract

As part of our continuing search for potential anticancer drug candidates, we have synthesized four 10-methoxycamptothecin derivatives. The compounds were synthesized by facile procedures and characterized by ¹H NMR, ¹³C NMR and mass spectra study. The synthesized compounds were examined for their cytotoxic effect on a panel of five human cancer cell lines. Three out of five compounds were found to exhibit moderate anticarcinogenic activities in all cell lines. The result of the present investigation encourage us to develop more other related compounds and to screen them for a wide range of biological activity.

Keywords

10-Methoxycamptothecin derivative Anticancer Cytotoxic

Zhu, M., Jing, L., Wang, S., Zhang, S., & Wang, Y. (2015). Synthesis and Anticancer Evaluation of Novel 10-Methoxycamptothecin Derivatives. Asian Journal of Chemistry, 27(3), 932–934. https://doi.org/10.14233/ajchem.2015.17599

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References

M.E. Wall, M. Wani, C. Cook, K.H. Palmer, A. McPhail and G. Sim, J. Am. Chem. Soc., 88, 3888 (1966); doi:10.1021/ja00968a057.

C.G. Moertel, A.J. Schutt, R. Reitemeier and R. Hahn, Cancer Chemother. Rep., 56, 95 (1972).

J. Fassberg and V.J. Stella, J. Pharm. Sci., 81, 676 (1992); doi:10.1002/jps.2600810718.

Y.-H. Hsiang, R. Hertzberg, S. Hecht and L. Liu, J. Biol. Chem., 260, 14873 (1985).

T.G. Burke and Z. Mi, Anal. Biochem., 212, 285 (1993); doi:10.1006/abio.1993.1325.

J.A. Gottlieb, Cancer Chemother. Rep., 56, 103 (1972).

A.W. Nicholas, M.C. Wani, G. Manikumar, M.E. Wall, K.W. Kohn and Y. Pommier, J. Med. Chem., 33, 972 (1990); doi:10.1021/jm00165a014.

M. Odagi, K. Furukori, T. Watanabe and K. Nagasawa, Chem. Eur. J., 19, 16740 (2013); doi:10.1002/chem.201303006.

A. Veloso, B. Biewen, M.T. Paulsen, N. Berg, L. Carmo de Andrade Lima, J. Prasad, K. Bedi, B. Magnuson, T.E. Wilson and M. Ljungman, PLoS ONE, 8, e78190 (2013); doi:10.1371/journal.pone.0078190.

N.M. Carballeira, N. Montano, R. Alvarez-Velilla, C.F. Prada, R.M. Reguera and R. Balana-Fouce, Mar. Drugs, 11, 3661 (2013); doi:10.3390/md11103661.

J.M. Wan, W.H. Sit, X. Yang, P. Jiang and L.L. Wong, Chin. Med., 5, 16 (2010); doi:10.1186/1749-8546-5-16.

L.D. Hicks, J.L. Hyatt, S. Stoddard, L. Tsurkan, C.C. Edwards, R.M. Wadkins and P.M. Potter, J. Med. Chem., 52, 3742 (2009); doi:10.1021/jm9001296.

M. Wierdl, C.L. Morton, L.C. Harris, M.K. Danks, J.D. Schuetz and P.M. Potter, J. Pharmacol. Exp. Ther., 304, 699 (2003); doi:10.1124/jpet.102.044149.

Z.S. Cao, J. Mendoza, A. Dejesus and B. Giovanella, Acta Pharmacol. Sin., 26, 235 (2005); doi:10.1111/j.1745-7254.2005.00031.x.

Q. Li, W. Qiu, Q. Zhu, Y. Zu, X. Deng, T. Zhao, C. Jiang and L. Zhang, Molecules, 16, 7803 (2011); doi:10.3390/molecules16097803.

H.G. Lerchen, J. Baumgarten, K. von dem Bruch, T.E. Lehmann, M. Sperzel, G. Kempka and H.H. Fiebig, J. Med. Chem., 44, 4186 (2001); doi:10.1021/jm010893l.

M.C. Wani, P.E. Ronman, J.T. Lindley and M.E. Wall, J. Med. Chem., 23, 554 (1980); doi:10.1021/jm00179a016.

T. Mosmann, J. Immunol. Methods, 65, 55 (1983); doi:10.1016/0022-1759(83)90303-4.

Z. Chen, Y.M. Liu, S. Yang, B.A. Song, G.F. Xu, P.S. Bhadury, L.H. Jin, D.Y. Hu, F. Liu, W. Xue and X. Zhou, Bioorg. Med. Chem., 16, 1337 (2008); doi:10.1016/j.bmc.2007.10.072.

Issue

Vol. 27 No. 3 (2015): Vol 27 Issue 3

Synthesis and Anticancer Evaluation of Novel 10-Methoxycamptothecin Derivatives

Corresponding Author(s) : Yang Wang

Abstract

Keywords

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