Antioxidant Activity and Melanogenesis Inhibitory Effect of Acerola Fruit (Malpighia glabra L.) Aqueous Extract and Its Safe Use in Cosmetics

Ling Wang; Fuheng Li; Congfen He; Yinmao Dong; Qi Wang

doi:10.14233/ajchem.2015.17771

Issue

Vol. 27 No. 3 (2015): Vol 27 Issue 3

Issue Published : January 19, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Antioxidant Activity and Melanogenesis Inhibitory Effect of Acerola Fruit (Malpighia glabra L.) Aqueous Extract and Its Safe Use in Cosmetics

https://doi.org/10.14233/ajchem.2015.17771

Ling Wang

School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang Province, P.R. China

Fuheng Li

School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang Province, P.R. China

Congfen He

School of Science, Beijing Technology and Business University, Beijing, P.R. China

Yinmao Dong

School of Science, Beijing Technology and Business University, Beijing, P.R. China

Qi Wang

School of Science, Beijing Technology and Business University, Beijing, P.R. China

Corresponding Author(s) : Fuheng Li

lifuheng1963@126.com

Asian Journal of Chemistry, Vol. 27 No. 3 (2015): Vol 27 Issue 3
Article Published : January 18, 2015

Abstract

Acerola (Malpighia glabra L.) fruit is well known as an excellent dietary source of vitamin C and many other phytochemicals. We investigated the effects of aqueous extract of acerola fruit on melanogenesis in B16 mouse melanoma cells and antioxidant activity. Aqueous extract of acerola fruit significantly reduced the cellular melanin level and inhibited tyrosinase activity in a concentration-dependent manner. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging tests indicated that aqueous extract of acerola fruit has potent antioxidative activity. These results suggested that aqueous extract of acerola fruit might be effective in skin-whitening and that its inhibitory effect on melanogenesis is due to a decrease in intracellular tyrosinase as determined by levels of gene expression (mRNA) and enzyme activity. The hemolysis rate after exposure to aqueous extract of acerola fruit was less than 10 %, below the 20 % regulatory limit for the red blood cell test. No allergic reactions were observed in the human skin patch tests. Hence, aqueous extract of acerola fruit could become an effective component in antiaging foods and whitening cosmetics.

Keywords

Malpighia glabra L. Antioxidant activity Tyrosinase B16 mouse melanoma cell Skin-whitening agent

Wang, L., Li, F., He, C., Dong, Y., & Wang, Q. (2015). Antioxidant Activity and Melanogenesis Inhibitory Effect of Acerola Fruit (Malpighia glabra L.) Aqueous Extract and Its Safe Use in Cosmetics. Asian Journal of Chemistry, 27(3), 957–960. https://doi.org/10.14233/ajchem.2015.17771

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References

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K. Urabe, J. Nakayama and Y. Hori, in eds.: J.J. Nordlund, R.E. Boissy, V.J. Hearing, R.A. King, W.S. Oetting and J.P. Ortonne, Mixed Epidermal and Dermal Hypermelanoses. The Pigmentary System: Physiology and Pathophysiology, Oxford University Press, New York, pp. 909-913 (1998).

M.K. Cullen, Genetic Epidermal Syndromes: Disorders Characterized by Lentigines, In: The Pigmentary System: Physiology and Pathophysiology, Oxford University Press, New York, pp. 760-766 (1998).

V.J. Hearing, J. Invest. Derm. Symp., 4, 24 (1999); doi:10.1038/sj.jidsp.5640176.

V.J. Hearing and M. Jimenez, Pigment Cell Res., 2, 75 (1989); doi:10.1111/j.1600-0749.1989.tb00166.x.

K. Maeda and M. Fukuda, J. Pharmacol. Exp. Ther., 276, 765 (1996).

H. Shimogaki, Y. Tanaka, H. Tamai and M. Masuda, Int. J. Cosmet. Sci., 22, 291 (2000); doi:10.1046/j.1467-2494.2000.00023.x.

J. Cabanes, S. Chazarra and F. Garcia-Carmona, J. Pharm. Pharmacol., 46, 982 (1994); doi:10.1111/j.2042-7158.1994.tb03253.x.

P.D. Johnson. In eds.: A.P. Simopoulos and C. Gopalan, Acerola (Malpighia glabra L., M. punicifolia L., M. emarginata D.C.): Agriculture, Production and Nutrition, In: Plants in Human Health and Nutrition Policy, World Rev. Nutr. Diet. Basel, Karger, vol. 91, pp. 67-75 (2003).

V.L.A.G. Lima, E.A. Melo, M.I.S. Maciel, F.G. Prazeres, R.S. Musser and D.E.S. Lima, Food Chem., 90, 565 (2005); doi:10.1016/j.foodchem.2004.04.014.

S.A. de Assis, D.C. Lima and O.M.M. de Faria Oliveira, Food Chem., 74, 133 (2001); doi:10.1016/S0308-8146(01)00104-2.

M. Roberfroid, Dig. Liver Dis., 34, 105 (2002); doi:10.1016/S1590-8658(02)80176-1.

A.L. Vendramini and L.C. Trugo, Food Chem., 71, 195 (2000); doi:10.1016/S0308-8146(00)00152-7.

T. Mezadri, D. Villaño, M.S. Fernández-Pachón, M.C. García-Parrilla and A.M. Troncoso, J. Food Compos. Anal., 21, 282 (2008); doi:10.1016/j.jfca.2008.02.002.

A.M. Righetto, F.M. Netto and F. Carraro, Food Sci. Technol. Int., 11, 315 (2005); doi:10.1177/1082013205056785.

J. Zhao, J.X. Lai, C.F. He, H. Zhao, Y.D. Yang and Y.M. Dong, China Surf. Deterg. Cosmet., 39, 402 (2009).

J. Hosoi, E. Abe, T. Suda and T. Kuroki, Cancer Res., 45, 1474 (1985).

L.C. Wu, L.H. Chang, S.H. Chen, N.C. Fan and J.A.A. Ho, LWT- Food Sci. Technol., 42, 1513 (2009); doi:10.1016/j.lwt.2009.04.004.

Z.W. Qiao, Y. Koizumi, M.X. Zhang, M. Natsui, M.J. Flores, L. Gao, K. Yusa, S. Koyota and T. Sugiyama, Biosci. Biotechnol. Biochem., 76, 1877 (2012); doi:10.1271/bbb.120341.

J.Y. Xue, X.F. Yang, Y. Yang, M. Zhao, J.M. Huang, X.K. Xiong and X.H. Tan, China Occup. Med., 37, 469 (2010).

A. Lagarto, R. Vega, Y. Vega, I. Guerra and R. Gonzalez, Toxicol. In Vitro, 20, 529 (2006); doi:10.1016/j.tiv.2005.10.001.

W.G. Zhang, X.F. Yang, Y. Yang, X. Li, X.K. Xiong, X.P. Xie and X. Tan, Chin. J. Prev. Med, 6, 544 (2010).

Y.X. Zheng, G.L. Xing, J. Wang and S.Y. Wang, Glob. Seabuckthorn Res. Dev., 6, 16 (2008).

Ministry of Health of the People’s Republic of China, Hygienic Standard for Cosmetics, Zhijian Publishing House, Beijing, China, p. 149, 219 (2002).

S.I.R. Franke, D. Pra, J. Silva, B. Erdtmann and J.A.P. Henriques, Mutat. Res., 583, 75 (2005); doi:10.1016/j.mrgentox.2005.03.001.

Y.K. Choi, Y.K. Rho, K.H. Yoo, Y.Y. Lim, K. Li, B.J. Kim, S.J. Seo, M.N. Kim, C.K. Hong and D.S. Kim, Int. J. Dermatol., 49, 218 (2010); doi:10.1111/j.1365-4632.2009.04336.x.

R. Silva Nunes, V.F.S. Kahl, M. Silva Sarmento, M.F. Richter, L.V. Costa-Lotufo, F.A.R. Rodrigues, J.A. Abin-Carriquiry, M.M. Martinez, S. Ferronatto, A. Barros Falcão Ferraz and J. Silva, Plant Foods Hum. Nutr., 66, 129 (2011); doi:10.1007/s11130-011-0223-7.

Issue

Vol. 27 No. 3 (2015): Vol 27 Issue 3

Antioxidant Activity and Melanogenesis Inhibitory Effect of Acerola Fruit (Malpighia glabra L.) Aqueous Extract and Its Safe Use in Cosmetics

Corresponding Author(s) : Fuheng Li

Abstract

Keywords

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